子痫前期治疗前后血浆NT-proBNP和炎性细胞因子水平的变化

陈大立; 许咏梅; 彭兰; 杨永青; 柴利强

doi:10.7619/jcmp.201417021

子痫前期治疗前后血浆NT-proBNP和炎性细胞因子水平的变化

1.
南京医科大学附属苏州医院苏州母子医疗保健中心产科，江苏苏州，215002;
2.
南京医科大学附属苏州医院苏州母子医疗保健中心核医学科，江苏苏州，215002

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- 发布日期: 2014-10-16

Changes of plasma NT-proBNP and inflammatory cytokines levels before and after treatment for preeclampsia

摘要

摘要: 目的：探讨子痫前期治疗前后血浆N氨基末端脑利钠肽前体（NT-proBNP）和炎性细胞因子水平的变化。方法以荧光免疫分析、放射免疫分析和超敏酶免疫分析法分别测定了93例子痫患者（其中45例轻度和48例重度）血浆中NT-proBNP、IL-6、hs-CRP和TNF-α水平，并与42例正常对照组进行对比分析。结果93例子痫患者治疗前血浆NT-proBNP、IL-6、hs-CRP和TNF-α水平较42例正常对照组明显增高（P均＜0．01），并随子痫前期的严重程度而增加。治疗后45例轻度子痫前期患者血浆NT-proBNP、IL-6、hs-CRP和TNF-α水平恢复至正常，48例重度子痫前期患者除血浆中IL-6恢复至正常水平外（P＞0．05），血浆NT-proBNP、hs-CRP和TNF-α水平明显降低，但较正常对照组仍增高（P 均＜0．05）。结论血浆NT-proBNP和炎性细胞因子参与子痫前期发生、发展的病理生理过程，是考核子痫前期治疗的有效指标。
- 子痫前期 /
- N氨基末端脑利钠肽前体 /
- 炎性细胞因子 /
- 有效指标
Abstract: Obj ective To explore changes of plasma NT-proBNP and inflamatory cytokines levels before and after treatment for preeclampsia.Methods The levels of NT-proBNP(with fluore-scent immunoassay)and infammatory cytokines(IL-6 ,hs-CRP and TNF-αwith high-sensitive en-zyme immunoassay and radio immunoassay)in plasma were detected in 93 patients with preeclamp-sia (including 45 cases of light pre-eclampsia and 48 cases of severe pre-eclampsia),and 42 normal people were collected and detected for contrastive analysis.Results Before treatment,the plasma NT-proBNP and inflammatory cytokines (IL-6 ,hs-CRP and TNF-α)levels in 93 patients with preeclampsia were significantly higher than those in 42 normal people (P<0 .0 1 ).The plasma NT-proBNP,IL-6,hs-CRP and TNF-αlevels increased with increasing degree of preeclampsia.After treatment,the levels of NT-proBNP,IL-6,hs-CRP and TNF-αin 45 patients with light pre-eclampsia reached to normal level (P>0 .05 ).Though the plasma IL-6 level reached to normal lev-el,the levels of NT-proBNP,hs-CRP and TNF-αin 48 patients with severe pre-eclampsia were sig-nificantly higher than those in 42 normal people (P<0 .05 ).Conclusion The plasma NT-proBNP and inflammatory cytokines participate in pathogenesis process of preeclampsia,and these two indi-cators are effective monitoring index for the early treatment of preeclampsia.
- preeclampsia /
- N-ternimal pro-B-type natriuretic peptide /
- inflammatory cy-tokines /
- effective index

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子痫前期治疗前后血浆NT-proBNP和炎性细胞因子水平的变化

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Changes of plasma NT-proBNP and inflammatory cytokines levels before and after treatment for preeclampsia

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