多索茶碱不同给药方式对 APACHEⅡ评分不同的慢性阻塞性肺疾病急性加重期撤机时间的影响

王磊; 李树铁; 原娜

doi:10.7619/jcmp.201416035

多索茶碱不同给药方式对 APACHEⅡ评分不同的慢性阻塞性肺疾病急性加重期撤机时间的影响

河北北方学院附属第一医院 ICU，河北张家口，075000

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中图分类号: R441.8
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- 发布日期: 2014-09-10

Effects of doxophylline of different administration methods on weaning time of acute exacerbation of chronic obstructive pulmonary diseases of APACHEⅡ score

摘要

摘要: 目的：探讨 APACHEⅡ评分不同的慢性阻塞性肺疾病急性加重期（AECOPD）患者应用多索茶碱不同给药方式对机械通气撤机时间的影响。方法选取本院 ICU 病房 AECOPD 病人经有创机械通气治疗并成功脱机患者45例，其中 A-PACHEⅡ＜20使用多索茶碱持续泵入组13例和静点组11例，APACHEⅡ≥20多索茶碱持续泵入组11例和静点组10例，观察不同 APACHEⅡ评分病人多索茶碱持续泵入组与多索茶碱静点组对机械通气撤机时间的影响。结果多索茶碱持续泵入组在 APACHEⅡ＜20的撤机时间早于多索茶碱静点组，差异有统计学意义（P ＜0．05）；与 APACHEⅡ≥20比较，多索茶碱持续泵入组与多索茶碱静点组差异无统计学意义（P ＞0．05）。结论 AECOPD 机械通气撤机时间受 APACHEⅡ评分影响，多索茶碱持续泵入治疗能缩短 APACHEⅡ＜20机械通气时间，提高脱机率。
- 多索茶碱 /
- AECOPD /
- APACHEⅡ评分系统 /
- 机械通气
Abstract: Objective To study effects of doxophylline of different administration methods on weaning time of acute exacerbation of chronic obstructive pulmonary diseases(AECOPD)of A-PACHEⅡ score.Methods 45 patients with AECOPD treated with mechanical ventilation and successful ventilator weaning were selected.In APACHEⅡ<20 patients,13 cases with doxo-fylline by continuous pump were in continuous pump group and 11cases in intravenous drip group;In APACHEⅡ≥20 patients,there were doxofylline by continuous pump with 11 cases and Doxo-fylline by intravenous drip with 10 cases,the effect of ventilator weaning time in different A-PACHEⅡscore between doxofylline by continuous pump and intravenous drip were observed.Re-sults The ventilator weaning time of doxofylline by continuous pump and intravenous drip were compared in APACHEⅡ<20,which was statistically significant difference (P <0.05).but there was no significant difference in APACHEⅡ≥20(P >0.05).Conclusion Ventilator weaning time of AECOPD is influenced by APACHEⅡ score.Continuous pump into doxofylline can obvi-ously relieve mechanical ventilation time in APACHEⅡ<20 and improve the rate of weaning time.
- doxofylline /
- AECOPD /
- APACHEⅡscore /
- mechanical ventilation

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1.	周小果，党强，李海剑，门翔，路尧. 特发性炎性肌病间质性肺炎患者并发肺部感染病原菌及危险因素. 中华医院感染学杂志. 2024(08): 1150-1153 . 百度学术
2.	杨洁，沈娟. 1例老年天疱疮患者合并耶氏肺孢子菌肺炎的药学监护. 中国药物应用与监测. 2023(03): 172-175 . 百度学术

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多索茶碱不同给药方式对 APACHEⅡ评分不同的慢性阻塞性肺疾病急性加重期撤机时间的影响

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Effects of doxophylline of different administration methods on weaning time of acute exacerbation of chronic obstructive pulmonary diseases of APACHEⅡ score

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