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卵胞浆内单精子显微注射对逆行射精致男性不育症的治疗价值

季兴哲, 张洲, 周梁, 王辉, 薛霞, 刘项

季兴哲, 张洲, 周梁, 王辉, 薛霞, 刘项. 卵胞浆内单精子显微注射对逆行射精致男性不育症的治疗价值[J]. 实用临床医药杂志, 2014, (13): 60-62. DOI: 10.7619/jcmp.201413019
引用本文: 季兴哲, 张洲, 周梁, 王辉, 薛霞, 刘项. 卵胞浆内单精子显微注射对逆行射精致男性不育症的治疗价值[J]. 实用临床医药杂志, 2014, (13): 60-62. DOI: 10.7619/jcmp.201413019
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JI Xingzhe, ZHANG Zhou, ZHOU Liang, WANG Hui, XUE Xia, LIU Xiang. Therapeutic value of intracytoplasmic sperm injection on retrograde ejaculation-induced male infertility[J]. Journal of Clinical Medicine in Practice, 2014, (13): 60-62. DOI: 10.7619/jcmp.201413019
Citation: JI Xingzhe, ZHANG Zhou, ZHOU Liang, WANG Hui, XUE Xia, LIU Xiang. Therapeutic value of intracytoplasmic sperm injection on retrograde ejaculation-induced male infertility[J]. Journal of Clinical Medicine in Practice, 2014, (13): 60-62. DOI: 10.7619/jcmp.201413019
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卵胞浆内单精子显微注射对逆行射精致男性不育症的治疗价值

  • 陕西省妇幼保健院 辅助生殖中心，陕西 西安，710003

基金项目: 中国高校医学期刊临床专项资金
详细信息

  • 中图分类号: R698

Therapeutic value of intracytoplasmic sperm injection on retrograde ejaculation-induced male infertility

摘要

    摘要
  • 摘要: 目的：探讨卵胞浆内单精子显微注射（ICSI）对逆行射精导致的男性不育症的临床治疗价值。方法选取2007年4月-2012年6月在本中心诊治的10例逆行射精患者为研究对象，治疗当天，患者有射精感后立即排尿，留取尿液立即加入培养液，离心清洗后，直接制盘行 ICSI 治疗；女方采用常规促性腺激素释放激素激动剂（GnRH-a）长方案超促排卵，经阴道穿刺取卵后采用 ICSI 方式授精。结果10例逆行射精症患者共完成19个治疗周期，其中2例患者的4个治疗周期因取精当日未发现运动精子改行睾丸穿刺取精加 ICSI 治疗。其余8例逆行射精患者，共完成15个治疗周期，包括10个新鲜周期和5个冷冻胚胎解冻移植（FET）周期，总受精率为67．97％，卵裂率94．25％，新鲜周期临床妊娠率为66．67％，FET 周期临床妊娠率为60％，总临床妊娠率为64．28％。结论 ICSI 治疗逆行射精导致的男性不育症，疗效确切。对于药物及手术治疗无效的逆行射精不育症患者，ICSI 是解决其生育问题的很好选择。
    Abstract: Objective To explore the clinical therapeutic value of intracytoplasmic sperm in-jection (ICSI)on retrograde ejaculation-induced male infertility.Methods A total of 10 male pa-tients with retrograde ejaculation-induced male infertility in this center served as research objects. On treatment day,male patients had to urinate immediately after the presence of ejaculation sensa-tion,urine was collected and added with culture medium,centrifuged and cleaned,and directly es-tablish gel to conduct ICSI.As for females,routine gonadotropin-releasing hormone angonist (GnRH-a)was applied to conduct long-protocol controlled ovarian hyperstimulation,and ISCI was conducted for insemination after egg retrival by trans-vaginal puncture.Results All male patients were successfully complete 19-cycle treatment,in which 2 were treated with testicular puncture to collect sperms and ICSI because no movement sperm was found after 4-cycle treatment,while the rest patients finished 15-cycle treatment,including 10 fresh cycles and 5 frozen embryos thawing transplantation (FET)cycles,with total insemination rate,merogenesis rate,clinical pregnancy rate in fresh cycle ,clinical pregnancy rate in FET cycle and total clinical pregnancy rate being 67.97%,94.25%,66.67%,60% and 64.28%,respectively.Conclusion ISCI has certain effi-cacy and is the optimal choice in treating retrograde ejaculation-induced male infertility poor with surgeries.
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  • 发布日期:  2014-09-10

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