IL-6、IL-8对监测胎膜早破孕妇绒毛膜羊膜炎的临床价值

付晓辉; 李广鲲; 李秀莲

doi:10.7619/jcmp.201413017

IL-6、IL-8对监测胎膜早破孕妇绒毛膜羊膜炎的临床价值

1.
河北省承德县医院妇产科，河北承德，067400;
2.
河北省承德市双桥区疾病预防控制中心，河北承德，067000

基金项目: 中国高校医学期刊临床专项资金

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中图分类号: R714.43
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出版历程
- 发布日期: 2014-09-10

Clinical value of IL-6 and IL-8 in monitoring chorioamnionitis of pregnant women with premature rupture of membrane

摘要

摘要: 目的：探讨白细胞介素-6（IL-6）和白细胞介素8（IL-8）对监测胎膜早破（PROM）孕妇绒毛膜羊膜炎的临床价值。方法选择在本院分娩的 PROM 孕妇45例作为研究组，同时选择同期在本院分娩的正常孕妇30例作为对照组，采用酶联免疫吸附法（ELISA）测定2组血清 IL-6及 IL-8水平，并于产后取胎膜组织做病理检查。结果研究组血清 IL-6及 IL-8水平显著高于对照组，差异有统计学意义。研究组产后胎膜组织病理检查诊断为绒毛膜羊膜炎28例（62．2％）为感染组，非绒毛膜羊膜炎17例（37．8％）为非感染组，感染组血清 IL-6及 IL-8水平显著高于非感染组，差异均有统计学意义。结论孕妇血清中IL-6及 IL-8的联合检测可作为监测 PROM 合并绒毛膜羊膜炎的重要指标。
- 胎膜早破 /
- 白细胞介素-6 /
- 白细胞介素8 /
- 绒毛膜羊膜炎
Abstract: Objective To explore the clinical value of interleukin-6 (IL-6)and interleukin-8 (IL-8)in monitoring chorioamnionitis of pregnant women with premature rupture of membrane (PROM).Methods Forty-five pregnant women with PROM delivered in our hospital were select-ed as research group,and 30 normal pregnant women in our hospital were collected as control group at the same term.The levels of serum IL-6 and IL-8 in both groups were detected with enzyme-linked immunosorbent assay (ELISA),and the fetal membrane tissues were taken to conduct patho-logical examination after delivery.Results The levels of serum IL-6 and IL-8 in research group were significantly higher than in control group,with statistical significance.According to the patho-logical examination on fetal membrane tissues,28 patients (62.2%)were diagnosed as chorioam-nionitis (infection group),and 17 ones (37.8%)were not (non-infection group).The levels of serum IL-6 and IL-8 in infection group were significantly higher than in non-infection group,in which significant differences were presented.Conclusion Joint detection of IL-6 and IL-8 in serum of pregnant women can be used as the important index for monitoring PROM combined with chorioamnionitis.
- premature rupture of membrane /
- interleukin-6 /
- interleukin-8 /
- chorioam-nionitis

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