Influence of compound glutamine combined with probiotics on intestinal barrier function and cytokine in patients with ulcerative colitis
-
摘要: 目的：探讨复方谷氨酰胺与枯草杆菌二联活菌联合治疗活动期溃疡性结肠炎对患者肠道功能以及细胞因子的影响。方法66例溃疡性结肠炎患者随机分为观察组（n ＝33）与对照组（n ＝33），对照组给予美沙拉嗪治疗，观察组在对照组基础上加用枯草杆菌二联活菌与复方谷氨酰胺治疗，对比2组患者临床效果、肠道屏障功能（采用糖分子探针乳果糖/甘露醇比值，即 L /M 比值）以及细胞因子（IL-8及 TNF-α）的变化。结果观察组总有效率及结肠镜检查缓解率均为100．0％，显著高于对照组的81．8％及84．8％（P ＜0．05）；2组患者 IL-8及 TNF-α均较前显著减低（P ＜0．01），且治疗后观察组均显著低于对照组（P ＜0．01）；观察组患者 L /M 治疗后显著减低（P ＜0．01），对照组未见明显变化（P ＞0．05），治疗后观察组显著低于对照组（P ＜0．01）。结论传统治疗基础上联合益生菌与复方谷氨酰胺在 UC 治疗中具有确切的疗效，同时对于肠道屏障功能的恢复及细胞因子的降低也具有重要意义。Abstract: Objective To explore the influence of compound glutamine combined with pro-biotics on intestinal barrier function and cytokine in patients with ulcerative colitis (UC).Methods 66 patients with UC were randomly divided into the control group (n =33)and the observation group (n =33).The control group was treated with mesalazine,while the observation group was treated with compound and probiotics on the basis of control group.Clinical efficacy,intestinal bar-rier function and cytokine were compared between the two groups.Results The total effective rate and colonoscopy remission rate of the observation group were 100.0%,which were significantly higher than 81.8% and 84.8% of the control group (P <0.05).After the treatment,IL-8 and TNF-αwere significantly lower than those before treatment (P <0.01),and the indexes of the observation group were significantly lower than the control group (P <0.01).L /M in the observa-tion group was significantly lower than that before treatment and the control group (P <0.01),but there was no significant difference in the control group (P >0.05).Conclusion Compound glu-tamine combined with probiotics based on the traditional treatment shows significant effects in treat-ment of patients with UC,and it also has an important significance in the recovery of intestinal bar-rier function and reduction of cytokine.
-
Keywords:
- compound glutamine /
- probiotics /
- ulcerative colitis /
- intestinal barrier func-tion /
- cytokine
-
-
陈铭诗, 杜立阳. 溃疡性结肠炎的流行病学 [J]. 中国实用乡村医生杂志, 2013, (21):6. 解春静, 庄彦华, 栾雨茏. 溃疡性结肠炎发病机制中免疫因素的研究进展 [J]. 细胞与分子免疫学杂志, 2013(8):889. 李霞, 曲波, 姜海燕. 激素依赖型溃疡性结肠炎的治疗进展 [J]. 胃肠病学和肝病学杂志, 2013(1):95. 中华医学会消化病学分会炎症性肠病协作组. 对我国炎症性肠病诊断治疗规范的共识意见 [J]. 现代消化及介入诊疗, 2008(2):139. 冯百岁, 刘占举, 牛正先. 美沙拉嗪治疗溃疡性结肠炎的临床疗效及对血清 TNF-α和 IL-8 的影响 [J]. 郑州大学学报(医学版), 2006(5):830. 罗凤燕, 白爱平. 溃疡性结肠炎动物模型的研究进展 [J]. 世界华人消化杂志, 2013(7):607. 樊慧丽, 陈玉梅. 溃疡性结肠炎的发病机制和治疗进展 [J]. 中国全科医学, 2012(2):228. 姚应琴, 张亚梅, 崔翔. 口服益生菌联合康复新液灌肠治疗溃疡性结肠炎疗效观察 [J]. 现代中西医结合杂志, 2013(1):44. 翟莉莉, 李俊霞, 沈女吉. 谷氨酰胺对溃疡性结肠炎病人结肠上皮细胞增殖的影响 [J]. 肠外与肠内营养, 2012(2):71. 苗政, 钱家鸣, 李景南. 两种溃疡性结肠炎小鼠模型的构建及其炎症反应机制比较 [J]. 协和医学杂志, 2010(2):145. 王旭霞, 赵曙光, 刘震雄. 双歧杆菌对溃疡性结肠炎大鼠肠黏膜屏障功能及细胞因子的影响 [J]. 山西医科大学学报, 2011(8):621. 王东, 陈德国, 武华. 复合膳食纤维对溃疡性结肠炎患者肠黏膜屏障功能的影响 [J]. 中国医药导报, 2013(4):34. -
期刊类型引用(4)
1. 陆剑韬. 骨创伤治疗仪辅助外固定术对创伤性骨折患者的临床效果评价. 中国医疗器械信息. 2023(08): 40-42+181 . 
百度学术
2. 武亮霞，高玲，凌云. 基于快速康复理念的护理模式对面部外伤患者美容整形缝合术治疗效果的影响. 中国美容医学. 2022(04): 162-165 . 百度学术
3. 李丹丹，何清丽，王晓慧，毕云霞，芦丹丹. 口腔颌面创伤患者心理特征、心理需求特点及相关因素. 国际护理学杂志. 2022(12): 2146-2152 . 百度学术
4. 丁雪. 坚定内固定术在口腔颌面部创伤治疗中的应用效果及安全性探讨. 中西医结合心血管病电子杂志. 2020(19): 45+63 . 百度学术
其他类型引用(0)
计量
- 文章访问数: 319
- HTML全文浏览量: 44
- PDF下载量: 1
- 被引次数: 4
下载:
苏公网安备 32100302010246号
