The clinical study on the combined detection of mycoplasma pneumoniae and chlamydia pneumoniae of the patients with community acquired pneumonia
-
摘要: 目的：观察分析联合检测肺炎支原体（Mp）和肺炎衣原体（Cp）对社区获得性肺炎（CAP）患者的临床意义。方法选取1500例 CAP 患者作为研究对象，对其咽拭子标本中的 Mp 和 Cp DNA 进行检测，对主要病原菌进行培养和鉴定，观察比较患者的抗感染治疗方案和治愈率。结果本组 CAP 患者的病原体分布以 Mp、肺炎链球菌、流感嗜血杆菌和 Cp 的比例最大，而感染类型以2种病原体感染的比例最多；在本组患者的治疗过程中，β-内酰胺类抗菌药物的使用频率最高，应用β-内酰胺类联合大环内酯类或氟喹诺酮类药物治疗的患者的治愈率显著高于单独应用β-内酰胺类药物的患者（P ＜0．05）；在治疗Mp 或 Cp 单纯感染时，单独应用β-内酰胺类药物与应用β-内酰胺类联合大环内酯类或氟喹诺酮类药物治疗的患者治愈率无显著性差异（P ＞0．05）；在治疗细菌合并 Mp 或 Cp 感染时，应用β-内酰胺类联合大环内酯类或氟喹诺酮类药物的患者治愈率显著高于单独应用β-内酰胺类药物者（P ＜0．05）。结论 Mp 和 Cp 感染在 CAP 患者中比较多见，患者的主要感染类型是2种病原体的混合性感染，β-内酰胺类药物是治疗过程中常用药物，应用β-内酰胺类联合大环内酯类或氟喹诺酮类药物的抗感染方案可提高患者的治愈率，特别是在有细菌合并 Mp 或 Cp 感染时，可发挥显著疗效，临床医生应根据 Mp 或 Cp 的检测结果合理、有效地选择抗感染治疗方案。Abstract: Objective To observe and analyze the clinical significance of the combined de-tection of Mycoplasma pneumoniae (Mp)and Chlamydia pneumoniae (Cp)for the patients with community acquired pneumonia (CAP).Methods 1500 CAP patients were selected as the re-search objects.DNA of Mp and Cp in the throat swab specimens of the patients were detected and the main pathogenic bacteria were cultured and identified,and anti-infection treatment methods and the curative rate of the patients were observed and compared.Results The largest proportions in the distribution of pathogens of the CAP patients in this group were Mp,Streptococcus pneumo-niae,Haemophilus influenzae and Cp,and infection of two pathogens was the main type of infec-tion.In the course of treatment of the patients in this group,βlactam antibiotic drug usage fre-quency was highest,the curative rate of the patients treated with combined application ofβlactam and macrolides or fluoroquinolones drug was significantly higher than that of single application ofβlactam drugs (P <0.05).In the treatment of single Mp or Cp herpes infection,the difference was not significant in the curative rate between the patients treated with single application ofβlactam drugs and combined application ofβlactam and macrolides or fluoroquinolones drug (P > 0 .0 5 ). In the treatment of bacterial infection complicated with Mp or Cp infection,the curative rate of the patients treated with combined application ofβlactam and macrolides or fluoroquinolones drug was significantly higher than that of single application ofβlactam drugs (P <0.05).Conclusion Mp and Cp infections are commonly seen in CAP patients.The main type of infection of the patients is mixed infection of two pathogens.In the treatment process,βlactam drugs are com-monly used.The anti infection treatment of application combinedβlactam with macrolide or fluo-roquinolones can improve the curative rate.Especially in treatment of bacteria infection complicat-ed with Mp or Cp infection.The clinicians should choose reasonable and effective anti infection treatment methods on the basis of the detection results of Mp or Cp.
-
-
高鹏, 熊旭东. 社区获得性肺炎相关诊治进展 [J]. 深圳中西医结合杂志, 2013(2):113. 刘向欣, 尹素凤, 刘运秋. 医院与社区获得性肺炎患者病原菌分布及耐药性分析 [J]. 现代预防医学, 2013, (23):4469. 刘向欣, 刘运秋, 尹素凤. 社区获得性肺炎病原体分布及致病菌耐药性的变化 [J]. 现代预防医学, 2013, (24):4517. Ribeiro C F, Ferrari G F, Fioretto J R. Antibiotic treatment schemes for very severe community-acquired pneumonia in children:a randomized clinical study [J]. Rev Panam Salud Publica, 2011(6):444. Viasus D, Garcia-Vidal C, Gudiol F. Statins for com-munity acquired pneumonia:current state of the science [J]. Eur J Clin Microbiol Infect Dis, 2010(2):143. 李琳, 张颖. 儿童社区获得性肺炎病原学研究进展 [J]. 职业与健康, 2013, (11):1390. 刘青. 老年社区获得性肺炎临床特点及危险因素分析 [J]. 中华医院感染学杂志, 2013, (13):3101. Cho M C, Kim H, An D. Comparison of sputum and nasopharyngeal swab specimens for molecular diagnosis of Mycophasma pneumoniae, Chlamydophila pneumoniae, and Legionel a pneumophila [J]. Ann Lab Med, 2012(2):133. 王贵清, 王立波. 肺炎支原体致炎症机制的研究进展 [J]. 中外医学研究, 2013, (24):152. 杨利俊, 王鑫, 陈华. 肺炎支原体致病机制研究进展 [J]. 疾病监测与控制, 2013(4):223. 刘燕子, 刘伟. 支原体肺炎治疗研究进展 [J]. 内蒙古中医药, 2013, (21):122. 胡艳群, 贺庆芝, 吴移谋. 衣原体持续性感染的分子机制研究进展 [J]. 细胞与分子免疫学杂志, 2013, (12):1333. 杨明生, 钱俊华, 丁兴红. 肺炎衣原体感染与儿童哮喘急性发作的关系研究 [J]. 中华医院感染学杂志, 2013, (13):3182. 崔耀刚, 吕小宁, 何志奇. 肺炎衣原体感染与急性心肌梗死关系的研究 [J]. 中华医院感染学杂志, 2013, (15):3611. 陈锐, 刘伟, 刘建平. 肺炎衣原体肺炎发生的相关危险因素研究 [J]. 中国现代医生, 2011, (20):39. 杨新怀, 欧焕娇, 刘舜莉. 社区获得性肺炎患者抗菌药物使用情况分析 [J]. 中国医院药学杂志, 2013, (18):1537. 王明华, 贾雪冬, 刘明亮. 大环内酯与喹诺酮治疗社区获得性肺炎随机对照试验的 Meta 分析 [J]. 国外医药:抗生素分册, 2013(4):161. -
期刊类型引用(5)
1. 柳娇娜，谢娟. 四黄蜜中药涂擦联合中药熏洗在四肢骨折术后肢体肿胀的护理干预. 中国当代医药. 2024(13): 131-134 . 
百度学术
2. 丁晓飞，邹光翼，李婕. 超声中药透入对四肢骨折患者患肢肿胀、疼痛情况及骨愈合的影响分析. 辽宁中医杂志. 2023(03): 126-129 . 百度学术
3. 梁衍祥，张帅，颜林飞. 膝骨性关节炎采用关节镜关节腔清理术后活血化瘀药物超声导入治疗价值研究. 中外医学研究. 2022(01): 35-38 . 百度学术
4. 兰义芬，方炳木，江锦红，刘永华. 超声电导药物透入治疗联合甲钴胺片对多发性骨髓瘤化疗患者疼痛的影响. 广东医学. 2021(02): 202-205 . 百度学术
5. 林珑，王吟春，刘冠男，高丽霓，张辰浩. 中医治疗慢性心力衰竭利尿剂抵抗所致水肿的研究进展. 现代中西医结合杂志. 2021(06): 674-677 . 百度学术
其他类型引用(1)
计量
- 文章访问数: 383
- HTML全文浏览量: 50
- PDF下载量: 1
- 被引次数: 6
下载:
苏公网安备 32100302010246号
