星状神经节阻滞对大鼠乳腺增生模型激素水平的影响

孙志国; 蔡海峰; 王智云; 路延芹; 戴浩

doi:10.7619/jcmp.201409016

星状神经节阻滞对大鼠乳腺增生模型激素水平的影响

1.
河北省唐山市人民医院乳腺二科，河北唐山，063000;
2.
河北省唐山市人民医院药剂科，河北唐山，063000

基金项目: 中国高校医学期刊临床专项资金

详细信息

中图分类号: R339.2
计量
- 文章访问数: 222
- HTML全文浏览量: 50
- PDF下载量: 0
出版历程
- 发布日期: 2014-07-14

Effect of stellate ganglion block on hormone level in rats with breast hyperplasia

摘要

摘要: 目的：通过研究星状神经节阻滞（SGB）对于大鼠乳腺增生模型激素水平的调节，进一步探讨其对乳腺增生的影响机制。方法选取40只成年雌性未孕 Wistar 大鼠随机分成空白对照组、乳腺增生模型组、乳癖消组，乳癖消联合 SGB 组。对比分析各组大鼠的乳房直径、乳头高度、血清雌二醇（E2）、黄体酮（P）、催乳素（PRL）水平等指标。结果乳癖消联合 SGB 组大鼠的 E2、PRL 水平下降程度及 P 水平提高程度与乳癖组相比有显著性差异（P ＜0．05）。结论对于大鼠乳腺增生模型的干预中，联合应用 SGB 治疗能够有效调节其激素水平，明显减小乳房直径和乳头高度，达到更加有效的治疗效果。
- 星状神经节阻滞 /
- 乳腺增生 /
- 激素 /
- 大鼠 /
- 模型
Abstract: Objective To further explore the function mechanism of stellate ganglion block (SGB)on hormone level in rats with breast hyperplasia.Methods A total of 40 female rats were divided into four groups randomly:blank control group,model group (with breast hyperplasia), treatment group (with Rubixiao)and combined group (Rupixiao combined with SGB).The diame-ter of breast,the height of papilla,the levels of estradiol (E2 ),progesterone (P)and prolactin (PRL)were compared between two groups.Results The difference was significant in the de-creased level of E2 and PRL as well as increased P level between combined group and treatment group (P <0.05).Conclusion In the intervention of rats with breast hyperplasia,combined appli-cation of SGB can effectively regulate the hormone level and reduce the diameter of breast and the height of papilla so as to achieve more superior efficacy.
- stellate ganglion block /
- breast hyperplasia,hormone,rats /
- models

HTML全文

参考文献(0)

施引文献

资源附件(0)

计量

文章访问数: 222
HTML全文浏览量: 50
PDF下载量: 0
被引次数: 0

星状神经节阻滞对大鼠乳腺增生模型激素水平的影响

计量

出版历程

Effect of stellate ganglion block on hormone level in rats with breast hyperplasia

计量

出版历程

目录