Changes of C-reactive protein level and inflammatory factors in patients with obstructive sleep apnea syndrome
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摘要: 目的：观察和分析 C 反应蛋白及相关炎性因子变化在阻塞性睡眠呼吸暂停低通气综合征中的价值。方法选取2011年1月-2012年12月于本院就诊的205例阻塞性睡眠呼吸暂停低通气综合征者，且根据呼吸暂停低通气指数（AHI）等指标分为观察Ⅰ组（72例）、观察Ⅱ组（68例）和观察Ⅲ组（65例），以及健康对照组50例，同时监测对四4组患者 C 反应蛋白水平及白介素-6和白介素-18相关炎性因子水平，并对进行监测和所得数据进行的统计学处理分析。结果随着病情加重，呼吸暂停低通气指数（AHI）逐渐升高（AHI）、血氧饱和度下降、C 反应蛋白、白介素-6及白介素-18水平逐渐升高，且 Logistic 回归分析结果显示：C 反应蛋白、白介素-6和白介素-18与 AHI、血氧饱和度具有相关性，其中与 AHI 呈正相关性，、与血氧饱和度呈负相关性。结论 C-反应蛋白水平、白介素-6和白介素-18等相关炎性因子变化是评估阻塞性睡眠呼吸暂停低通气综合征中评估患者病情、指导临床治疗、判断疾病预后的重要指标，值得临床推广。
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关键词:
- C反应蛋白 /
- 白介素-6 /
- 白介素-18 /
- 阻塞性睡眠呼吸暂停低通气综合征
Abstract: Objective To observe and analyze the changes of C-reactive protein and inflam-matory factors in patients with obstructive sleep apnea syndrome.Methods 205 patients with ob-structive sleep apnea syndrome were divided into observation group Ⅰ (n =72),group Ⅱ (n =68) and observation group Ⅲ (n =65)according to apnea-hypopnea index (AHI),and the other 50 pa-tients were designed as control group.Levels of C-reactive protein,interleukin-6 and interleukin-18 were detected.Results The sicker,apnea-hypopnea index gradually increased (AHI),oxygen sat-uration decreased,C-reactive protein,interleukin-6 and interleukin-18 levels increased gradually. Logistic regression analysis showed that C-reactive protein,interleukin-6 and interleukin-18 and AHI,oxygen saturation were positively correlated with AHI and negatively correlated with oxygen saturation.Conclusion C-reactive protein level,interleukin-6 and interleukin-18 and other related inflammatory factors are the important indicators for prognosis judgment of patients with obstructive sleep apnea syndrome,so it is worthy of clinical application. -
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