汉语成语N400在神经衰弱和抑郁症患者事件相关电位检测中的应用研究

梁余航, 周曙, 陈湛愔

梁余航, 周曙, 陈湛愔. 汉语成语N400在神经衰弱和抑郁症患者事件相关电位检测中的应用研究[J]. 实用临床医药杂志, 2014, (1): 33-35. DOI: 10.7619/jcmp.201401010
引用本文: 梁余航, 周曙, 陈湛愔. 汉语成语N400在神经衰弱和抑郁症患者事件相关电位检测中的应用研究[J]. 实用临床医药杂志, 2014, (1): 33-35. DOI: 10.7619/jcmp.201401010
LIANG Yuhang, ZHOU Shu, CHEN Zhanyin. Application of Chinese idom-N400 in detection of event-related potential in patients with neurasthenia and depression[J]. Journal of Clinical Medicine in Practice, 2014, (1): 33-35. DOI: 10.7619/jcmp.201401010
Citation: LIANG Yuhang, ZHOU Shu, CHEN Zhanyin. Application of Chinese idom-N400 in detection of event-related potential in patients with neurasthenia and depression[J]. Journal of Clinical Medicine in Practice, 2014, (1): 33-35. DOI: 10.7619/jcmp.201401010

汉语成语N400在神经衰弱和抑郁症患者事件相关电位检测中的应用研究

详细信息
  • 中图分类号: R749.7

Application of Chinese idom-N400 in detection of event-related potential in patients with neurasthenia and depression

  • 摘要: 目的 采用汉语成语作为N400刺激物,探讨神经衰弱与抑郁症患者事件相关点位N400的关系.方法 选择2011年3月-2013年3月在本院心理门诊和住院的神经衰弱和抑郁症患者,并选取40例正常人作为对照组.采用汉语成语作为N400刺激物,观察受试者的N400的测量.结果 MMSE评分B组、A组、C组呈上升趋势,且两两之间比较均有显著差异(P均<0.01);HAMD-17总分B组、A组、C组呈逐渐下降趋势,且两两之间比较也均有显著差异(P均<0.01);N400潜伏期B组、A组、C组呈逐渐下降趋势,且两两之间比较均有显著差异(P均<0.05);N400波幅C组、A组、B组呈逐渐下降趋势,且A组与C组、B组与C组间存在显著差异(P均<0.01);抑郁症患者组的N400潜伏期延长与HAMD-17评分呈正相关关系(r=0.321,P=0.026).结论 相较于正常人,神经衰弱与抑郁症患者的思维减慢,对汉语成语的理解、抽象概括能力降低,且抑郁症患者表现得更为突出;抑郁症患者Cz脑区的N400潜伏期与HAMD-17评分是呈正相关的.
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出版历程
  • 发布日期:  2014-07-09

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