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摘要: 慢性心力衰竭(CHF)是多种心血管事件如急性冠状动脉综合征、心肌病、高血压病、心脏瓣膜疾病等发展至一定严重程度的终末转归.近年来,CHF患病率大为激增,致病机制又极其复杂,治疗手段进展缓慢,预后往往不良.血浆B型利钠肽(BNP)可反映CHF患者心脏收缩和舒张功能,是CHF早期诊断、风险评估及预后判断的有效指标[1].红细胞分布宽度(RDW)是反映红细胞体积异质性的参数,是红细胞体积大小不等程度的客观指标.RDW与CHF和冠心病的发生率及预后相关,RDW的升高是CHF患者预后不良的独立危险因素之一[2].
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Nishikimi T. Clinical significance of BNP as a biomarker for cardiac disease-from a viewpoint of basic science and clinical aspect [J]. Nihon Rinsho, 2012(5):774. Cauthen CA, Tong W, Jain A. Progressive rise in red cell distribution width is associated with disease progression in ambulatory patients with chronic heart failure [J]. {H}Journal of Cardiac failure, 2012(2):146. Wiwanitkit V. Plateletcrit, mean platelet volume, platelet distribution width:its expected values and correlation with parallel red blood cell parameters [J]. {H}Clin Appl Thrombosis/Hemostasis, 2004(2):175. Farmakis D, Parissis J T, Bistola V. Plasma B-type natriuretic peptide reduction predicts long-term response to levosimendan therapy in acutely decompensated chronic heart failure [J]. {H}International Journal of Cardiology, 2010(1):75. Clerico A, Vittorini S, Passino C. Circulating forms of the b-type natriuretic peptide prohormone:pathophysiologic and clinical considerations [J]. {H}Advances in Clinical Chemistry, 2012.31. Van Craenenbroeck E M, Pelle AJ, Beckers PJ. Red cell distribution width as a marker of impaired exercise tolerance in patients with chronic heart failure [J]. {H}European Journal of heart failure, 2012(1):54. Allen L A, Felker G M, Mehra M R. Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure [J]. {H}Journal of Cardiac failure, 2010(3):230. Pasic J, Sullivan M D, Russo J. Lack of depression effect on platelet activation in patients with heart failure [J]. {H}Psychiatry Research, 2004(3):289.
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