血清P-选择素联合尿微量蛋白检测对过敏性紫癜患儿肾损害的早期诊断价值

张霞军, 胡孟谋, 严晓慧

张霞军, 胡孟谋, 严晓慧. 血清P-选择素联合尿微量蛋白检测对过敏性紫癜患儿肾损害的早期诊断价值[J]. 实用临床医药杂志, 2013, (23): 52-55. DOI: 10.7619/jcmp.201323015
引用本文: 张霞军, 胡孟谋, 严晓慧. 血清P-选择素联合尿微量蛋白检测对过敏性紫癜患儿肾损害的早期诊断价值[J]. 实用临床医药杂志, 2013, (23): 52-55. DOI: 10.7619/jcmp.201323015
ZHANG Xiajun, HU Mengmou, YAN Xiaohui. Value of detection of serum P-selectin combined with microalbuminuria in early diagnosis of renal impairment of children with Henoch-Sch-nlein purpura[J]. Journal of Clinical Medicine in Practice, 2013, (23): 52-55. DOI: 10.7619/jcmp.201323015
Citation: ZHANG Xiajun, HU Mengmou, YAN Xiaohui. Value of detection of serum P-selectin combined with microalbuminuria in early diagnosis of renal impairment of children with Henoch-Sch-nlein purpura[J]. Journal of Clinical Medicine in Practice, 2013, (23): 52-55. DOI: 10.7619/jcmp.201323015

血清P-选择素联合尿微量蛋白检测对过敏性紫癜患儿肾损害的早期诊断价值

基金项目: 中国高校医学期刊临床专项资金
详细信息
  • 中图分类号: R554

Value of detection of serum P-selectin combined with microalbuminuria in early diagnosis of renal impairment of children with Henoch-Sch-nlein purpura

  • 摘要: 目的 探讨血清P-选择素联合尿微量蛋白检测对过敏性紫癜(HSN)患儿肾损害的早期诊断意义.方法 选择76例HSP患儿作为HSP组,并选取同期65例健康儿童作为对照组.采用常规放免法检测β2微球蛋白(β2-MG)、白蛋白(ALB)及转铁蛋白(TRF)含量,采用双抗夹心酶联免疫法测N乙酰-β-D-氨基葡萄糖苷酶(NAG)含量,血清肌酐(Scr)和尿素氮(BUN)测定运用终点法,血清P-选择素定量测定采用酶联免疫吸附法(ELISA).比较2组尿ALB、TRF、NAG、β2-MG及血清P-选择素的水平,并分析血清P-选择素水平与尿微量蛋白间的相关性.结果 HSP组患儿BUN及Scr水平均在正常范围内,且尿ALB、TRF、NAG、β2-MG及血清P-选择素水平均显著高于对照组患儿,差异有统计学意义;血清P-选择素水平与尿微量蛋白系列呈正相关;HSP组血清P-选择素及尿微量蛋白4项指标中的1项或>1项的异常率显著高于传统以尿常规阳性来判定早期肾损害的尿常规异常率,差异有统计学意义.结论 联合检测血清P-选择素及尿微量蛋白对HSP患儿的肾损害具有早期诊断价值.
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出版历程
  • 发布日期:  2014-04-08

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