Apelin/APJ系统与心血管疾病的研究进展

陈智伟, 陆士娟

陈智伟, 陆士娟. Apelin/APJ系统与心血管疾病的研究进展[J]. 实用临床医药杂志, 2013, (21): 199-202. DOI: 10.7619/jcmp.201321070
引用本文: 陈智伟, 陆士娟. Apelin/APJ系统与心血管疾病的研究进展[J]. 实用临床医药杂志, 2013, (21): 199-202. DOI: 10.7619/jcmp.201321070

Apelin/APJ系统与心血管疾病的研究进展

详细信息
  • 中图分类号: R714.252

  • 摘要: Apelin是G蛋白偶联受体APJ的天然配体,由于APJ受体发现在先,日本学者Tatemoto 等[1]采取反向药理学策略,将其从牛胃分泌物中提取并纯化出来,从而构成了Apelin/APJ系统.该系统在机体各大组织及器官均有广泛表达,具有多重生物学效应,如增强心肌收缩力、降低血压、促进新生血管形成、调节机体免疫反应及垂体相关激素的释放、调控胰岛素分泌等,其中对心血管系统的保护性作用尤为突出[2].至今,Apelin/APJ系统部分生物学效应、相关机制以及与某些疾病的联系已被阐明,但存在争议的部分仍有待进一步探讨,且其在机体新的效应及信号途径正被科研工作者逐步发掘.本文综合目前Apelin/APJ系统与心血管疾病关系的研究进展,并进行归纳总结.
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出版历程
  • 发布日期:  2014-04-07

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