紫杉醇、奥沙利铂联合氟尿嘧啶方案与S1+奥沙利铂方案在治疗进展期胃癌中的疗效对比研究

戴夕超, 张西志, 汪步海, 袁一枫, 王朝敏, 陈苏平, 张先稳, 陈丽, 蒋亚齐

戴夕超, 张西志, 汪步海, 袁一枫, 王朝敏, 陈苏平, 张先稳, 陈丽, 蒋亚齐. 紫杉醇、奥沙利铂联合氟尿嘧啶方案与S1+奥沙利铂方案在治疗进展期胃癌中的疗效对比研究[J]. 实用临床医药杂志, 2013, (21): 66-68,76. DOI: 10.7619/jcmp.201321018
引用本文: 戴夕超, 张西志, 汪步海, 袁一枫, 王朝敏, 陈苏平, 张先稳, 陈丽, 蒋亚齐. 紫杉醇、奥沙利铂联合氟尿嘧啶方案与S1+奥沙利铂方案在治疗进展期胃癌中的疗效对比研究[J]. 实用临床医药杂志, 2013, (21): 66-68,76. DOI: 10.7619/jcmp.201321018
Efficacy and safety of TOF and SOX regimens in the treatment of advanced gastric cancer[J]. Journal of Clinical Medicine in Practice, 2013, (21): 66-68,76. DOI: 10.7619/jcmp.201321018
Citation: Efficacy and safety of TOF and SOX regimens in the treatment of advanced gastric cancer[J]. Journal of Clinical Medicine in Practice, 2013, (21): 66-68,76. DOI: 10.7619/jcmp.201321018

紫杉醇、奥沙利铂联合氟尿嘧啶方案与S1+奥沙利铂方案在治疗进展期胃癌中的疗效对比研究

详细信息
  • 中图分类号: R735.2

Efficacy and safety of TOF and SOX regimens in the treatment of advanced gastric cancer

  • 摘要: 目的 比较紫杉醇、奥沙利铂联合氟尿嘧啶方案与S1+奥沙利铂方案在治疗晚期胃癌中的临床疗效和安全性.方法 选取60例经组织或细胞病理学证实的晚期胃癌患者,随机分为紫杉醇、奥沙利铂联合氟尿嘧啶组(TOF组)和S1+奥沙利铂组(SOX组),每组30例.TOF组治疗方案为:紫杉醇135mg/m2,第1天,使用前按照说明书要求进行预处理;氟尿嘧啶500mg/m2,化疗泵持续静脉滴注,第1~5天;奥沙利铂100mg/m2,静脉滴注2h,第1天.SOX组治疗方案为:替吉奥胶囊根据体表面积给药,体表面积<1.25 m2,40 mg,2次/d;体表面积1.25~1.50m2,50 mg,2次/d;体表面积>1.50 m2,60 mg,2次/d,早晚餐后口服,第1~14天;停药7d;奥沙利铂130mg/m2静脉滴注,第1天,21 d为一个周期.2个周期后评价疗效并记录毒副作用.结果 TOF组客观缓解率为43.3%,疾病控制率为60%,中位无进展生存(PFS)时间为6.5个月;SOX组客观缓解率为36.7%,疾病控制率为56.7%,中位无进展生存(PFS)时间为5.8个月.2组客观缓解率和疾病控制率比较差异无统计学意义.TOF组最常见的不良反应是骨髓抑制、恶心呕吐、口腔黏膜炎,SOX组主要为骨髓抑制.TOF组的不良反应发生率较SOX组更高.结论 两种方案治疗进展期胃癌均有成效,紫杉醇、奥沙利铂联合氟尿嘧啶方案不良反应更大,但患者均可耐受.
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  • 发布日期:  2014-04-07

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