Significance of microRNA-155 expression in gastric cancer
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摘要: 目的 探讨miRNA-155在胃癌组织中的表达及其临床意义.方法 收集30例行胃癌手术切除治疗患者的临床资料及胃癌组织,采用基于SYBR Green Ⅰ染料荧光分析的茎环real-time RT-PCR检测胃癌组织及其对应的癌旁组织中miRNA-155的表达水平(以U6作为内参).结果 miRNA-155在胃癌组织中表达量为(0.87±0.28),显著高于其在配对癌旁组织中(0.33±0.15)的表达量(P＜0.05);miRNA-155在有淋巴结转移的胃癌组织中表达更为显著(P＜0.05).结论 miRNA-155在胃癌组织中表达较癌旁组织明显上调.miRNA-155与胃癌的增殖、侵袭及转移密切相关,其可能成为胃癌的早期诊断及预后判断的新的生物学标记物.
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Keywords:
- micro RNA,gastric carcinoma /
- expression /
- significance
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