血清基质金属蛋白酶-3水平在不同OCSP亚型老年急性脑梗死患者血清中的变化

吴健; 陈应柱; 俞龙

doi:10.7619/jcmp.201321011

血清基质金属蛋白酶-3水平在不同OCSP亚型老年急性脑梗死患者血清中的变化

江苏省苏北人民医院,江苏扬州,225001

基金项目: 江苏省扬州市社会发展计划项目

详细信息

中图分类号: R743
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出版历程
- 发布日期: 2014-04-07

Changes of serum matrix metalloproteinase-3 levels in elderly patient with different subtypes of acute cerebral infarction

摘要

摘要: 目的观察不同临床亚型老年急性脑梗死(ACI)患者血清基质金属蛋白酶(MMP)-3水平变化及其与预后的关系.方法应用ELISA法检测258例发病3d内的老年ACI患者(病例组)和60例对照者(NC组)血清MMP-3,病例组根据牛津郡社区卒中计划(OCSP)分型标准分为完全性前循环型脑梗死(TACI)、部分前循环型脑梗死(PACI)、后循环型脑梗死(POCI)、腔隙性脑梗死(LACI)4大亚型,并进行美国国立卫生院卒中量表(NIHSS)、改良Rankin评分(mRS评分),分析不同OCSP亚型(MMP)-3水平变化及其与预后的相关性.结果 TACI、PACI、POCI患者血清MMP-3水平较NC组明显升高,差异有统计学意义(P＜0.01),LACI较NC组明显升高,差异有统计学意义(P＜0.05).TACI亚型90d时mRS评分0～2分患者比率最低,LACI亚型90 d时mRS评分0～2分患者比率最高,其次为PACI 、POCI亚型.结论血清MMP-3随OCSP亚型的不同而变化,发病后血清MBP可以作为老年脑梗死患者预后判断的指标之一.
- 急性脑梗死 /
- 基质金属蛋白酶3 /
- 牛津郡社区卒中计划(OCSP)
- acute brain infarction /
- matrix metaloproteinase-3 /
- Oxfordshire community stroke project (OCSP)

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参考文献(8)

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