胃癌组织调节性T细胞浸润的意义及机制

邓彬; 丁岩冰; 吴克艳; 梁钰; 庞磊; 肖炜明; 吴健; 张艳青; 卜平

doi:10.7619/jcmp.201321010

胃癌组织调节性T细胞浸润的意义及机制

1.
扬州大学附属第二临床医学院消化内科;
2.
扬州大学医学院,江苏扬州,225001

详细信息

中图分类号: R735.2
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- 文章访问数: 187
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出版历程
- 发布日期: 2014-04-07

Elucidation of underlying mechanism and clinical value of increased tumor-infiltrating regulatory T cells in gastric cancer tissue

摘要

摘要: 目的探讨胃癌组织中调节性T细胞(regulatory T cells,Tregs)浸润的临床意义和机制.方法免疫组织化学染色检测80例胃癌组织内Foxp3表达,分析Tregs浸润与胃癌患者临床因素的相关性,及其对预后的预测作用.流式细胞技术检测胃癌细胞株AGS细胞上清对Tregs趋化、诱导和增殖作用.结果 Foxp3在胃癌组织中的表达与淋巴结转移和临床分期相关,Foxp3低表达组患者生存期明显长于Foxp3高表达组患者(P=0.028).流式细胞技术检测显示AGS细胞上清组趋化Foxp3阳性T细胞比例较无血清培养基明显增加[(6.04±1.02)％与(2.19 ±0.19)％,P=0.011];经AGS细胞上清培养后Foxp3阳性T细胞比例较无血清培养基明显增加[(9.01±0.67)％与(7.68±0.80)％,P＜0.001];AGS细胞培养上清对Tregs增殖无明显作用.结论 Tregs在肿瘤组织内浸润可能与胃癌进展相关,对胃癌患者预后可能有预测作用,胃癌细胞可能通过分泌可溶性因子,趋化或诱导生成Tregs导致其在肿瘤中的浸润.
- 胃癌 /
- FoxP3 /
- 调节性T细胞 /
- 肿瘤免疫
- gastric cancer /
- FoxP3 /
- regulatory T cells /
- tumor immunity

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参考文献(13)

Parkin D M. Global cancer statistics in the year 2000 [J]. {H}LANCET ONCOLOGY, 2001(2):533.

Sakaguchi S, Yamaguchi T, Nomura T. Regulatory T cells and immune tolerance [J]. {H}CELL, 2008, (133):775.

Zou W. Regulatory T cells, tumour immunity and immunotherapy [J]. {H}Nature reviews Immunology, 2006(6):295.

Mougiakakos D, Choudhury A, Lladser A. Regulatory T cells in cancer [J]. {H}Advances in Cancer Research, 2010, (107):57.

Saknguchi S, Sakaguchi N, Asano M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25).Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases [J]. {H}Journal of Immunology, 1995(3):1151.

HoriS, NomuraT, Sakaguchi S. Controlof regulatory T cell development by the transcription factor Foxp3 [J]. {H}SCIENCE, 2003, (5609):1057.

Wang Y, Ma Y, Fang Y. Regulatory T cell:a protection for tumour cells [J]. {H}Jourmal Cell Mol Med, 2012(3):425.

Mizukami Y, Kono K, Kawaguchi Y. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3 + regulatory T cells in gastric cancer [J]. {H}International Journal of Cancer, 2008, (10):2286.

Gobert M, Treilleux I, Bendriss-Vermare N. Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome [J]. {H}CANCER RESEARCH, 2009(5):2000.

Zhang W, Wu K, He W. Transforming growth factor beta 1 plays an important role in inducing CD4+ 、CD25+ forhead box P3(+) regulatory T cells by mast cells [J]. {H}CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2010(3):490.

Liu Y, Zhang P, Li J. A critical function for TGF-beta signaling in the development of natural CD4+ CD25+ Foxp3 +regulatory T cells [J]. {H}Nature Immunology, 2008(6):632.

Cao M, Cabrera R, Xu Y. Hepatocellular carcinoma cell supernatants increase expansion and function of CD4 + 、CD25 + regulatory T cells [J]. {H}Laboratory Investigation, 2007(6):582.

Camisaschi C, Casati C, Rini F. LAG-3 expression defines a subset of CD4+ 、CD25 (high)Foxp3(+) regulatory T cells that are expanded at tumor sites [J]. {H}Journal of Immunology, 2010, (11):6545.

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文章访问数: 187
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胃癌组织调节性T细胞浸润的意义及机制

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出版历程

Elucidation of underlying mechanism and clinical value of increased tumor-infiltrating regulatory T cells in gastric cancer tissue

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