高敏C反应蛋白结合压力导丝在临界冠脉病变介入治疗中的应用效果评价

纪军; 何胜虎; 徐日新; 刘晓东; 陈述; 谢勇; 汪华玲; 廖清池

doi:10.7619/jcmp.201321004

高敏C反应蛋白结合压力导丝在临界冠脉病变介入治疗中的应用效果评价

江苏省苏北人民医院心内科,江苏扬州,225001

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中图分类号: R541.4
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- 发布日期: 2014-04-07

Application of high sensitivity C-reactive protein and pressure wire in dealing with critical lesion during coronary artery intervention

摘要

摘要: 目的探讨高敏C反应蛋白联合压力导丝检查对冠心病临界病变介入治疗的指导作用及对术后发生主要心脏不良事件的影响.方法 75例临床诊断冠心病患者术前检测高敏C反应蛋白(hs-CRP),经冠状动脉造影检查明确至少有1支主要冠状动脉狭窄程度在40％～70％,所有患者均行压力导丝检查测定血流储备分数(FFR).根据FFR值将患者分为PCI组和对照组,PCI组:对FFR＜ 0.75的病变行PCI治疗,其中根据hs-CRP值又分为hs-CRP升高组(≥3mg/L)和hs-CRP正常组(＜3 mg/L);对照组:对FFR≥0.75的病变予药物保守治疗.观察PCI组中患者病变处及支架植入数量,比较3组住院和随访期间发生典型心绞痛、非致死性心肌梗死、心源性死亡和靶血管重建等主要心脏不良事件(MACE)的发生率.结果 hsCRP升高PCI组共有31处临界狭窄病变,置入支架45枚;hs-CRP正常PCI组共有26处临界狭窄病变,置入支架29枚;2组患者在临界病变数及植入支架数方面比较差异均有统计学意义(P＜0.05).主要心脏不良事件方面,hs-CRP升高PCI组显著高于hs-CRP正常PCI组(P＜0.01);而hs-CRP正常PCI组与对照组比较无显著差别.结论 hs-CRP检测联合FFR检查可指导冠心病临界病变介入治疗,并可预测术后的心脏不良事件发生率.
- 临界冠脉病变 /
- 高敏C反应蛋白 /
- 血流储备分数 /
- 主要心脏不良事件
- coronary critical lesion /
- high sensitivity C-reactive protein /
- fractional flow reserve /
- major adverse cardiac events

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高敏C反应蛋白结合压力导丝在临界冠脉病变介入治疗中的应用效果评价

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Application of high sensitivity C-reactive protein and pressure wire in dealing with critical lesion during coronary artery intervention

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