宫颈上皮内瘤变患者血清IGF2检测的临床意义

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林红. 宫颈上皮内瘤变患者血清IGF2检测的临床意义[J]. 实用临床医药杂志, 2013, (19): 30-32. DOI: 10.7619/jcmp.201319010
引用本文: 林红. 宫颈上皮内瘤变患者血清IGF2检测的临床意义[J]. 实用临床医药杂志, 2013, (19): 30-32. DOI: 10.7619/jcmp.201319010
LIN Hong. Clinical significance of serum IGF2 detection in patients with cervical intraepithelial neoplasia[J]. Journal of Clinical Medicine in Practice, 2013, (19): 30-32. DOI: 10.7619/jcmp.201319010
Citation: LIN Hong. Clinical significance of serum IGF2 detection in patients with cervical intraepithelial neoplasia[J]. Journal of Clinical Medicine in Practice, 2013, (19): 30-32. DOI: 10.7619/jcmp.201319010

宫颈上皮内瘤变患者血清IGF2检测的临床意义

详细信息
  • 中图分类号: R711.74

Clinical significance of serum IGF2 detection in patients with cervical intraepithelial neoplasia

  • 摘要: 目的 探讨胰岛素样生长因子2在宫颈上皮内瘤变(CIN)患者体内的变化及意义.方法 应用ELISA法检测93例CIN患者(CIN Ⅰ级54例,Ⅱ级24例,Ⅲ级15例)和30例对照人群的血清IGF2水平.结果 随着CIN的病理分级的增高,其血清IGF2水平也逐渐增高,CINⅠ级的患者血清IGF2水平虽高于对照组,但无显著差异(P>0.05);CINⅡ患者血清IGF2水平与对照组比较有显著差异(P<0.05);CINⅢ级的患者血清IGF2水平最高,与对照组和CINⅠ级比较有显著差异(P<0.02和P<0.05),而与CINⅡ级比较无显著差异(P>0.05).以对照组血清IGF2水平的95%可信区间上限,确定的血清IGF2的阳性检测标准,CIN Ⅰ、Ⅱ、Ⅲ级患者的阳性率分别为11.11%、20.80%与60.00%,而对照组阳性率为0.00%,CINⅡ级和Ⅲ级的阳性率明显高于对照组(P=0.009和P=0.000).结论 血清IGF2的检测可作为宫颈上皮内瘤变向宫颈癌发展的监测指标之一.
  • Bergman D, Halje M, Nordin M. Insulin-like growth factor 2 in development and disease:a mini-review [J]. Gerontology, 2013(3):240.
    Serrano M L, Romero A, Cendales R. Serum levels of insulin-like growth factor-Ⅰ and-Ⅱ and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer [J]. Biomedicas, 2006(2):258.
    Petley T, Graff K, Jiang W. Variation among cell types in the signaling pathways by which IGF-Ⅰ stimulates specific cellular responses [J]. Hormone and Metabolic Research, 1999, (2/3):70.
    Bermont L, Lamielle F, Fauconnet S. Regulation of vascular endothelial growth factor expression by insulin-like growth factor-Ⅰ in endometrial adenocarcinorma cells [J]. International Journal of Cancer, 2000(1):117.
    Byme A T, Southgate J, Brison D R. Effects of insulin-like growth factors Ⅰ and Ⅱ on tumour-necrosis-factor-alpha-induced apoptosis in early murine embryos [J]. Reproduction, Fertility and Development, 2002, (1/2):79.
    Sarmani A A, Yakar S, LeRoith D. The role of the IGF system in cancer growth and metastasis:overview and recent insights [J]. Endocrine Reviews, 2007(1):20.
    Murphy S K, Huang Z, WenY. Frequent IGF2/H I9 domain epigenetic alrerations and elevated IGF2 expression in epithelial ovarian cancer [J]. Molecular Cancer Research, 2006(4):283.
    Mathur S P, Mathur R S, Underwood P B. Circulating levels of insulin-like growth factor-Ⅰ and IGF-binding protein 3 in cervical cancer [J]. Gynecologic Oncology, 2003(3):486.
    Serrano M L, Sánchez-Gómes M, Bravo M M. Insulinlike growth factor system gene expression in cervical scrapes from women with squamous intraepithelial lesions and cervical cancer [J]. Growth Hormone and IGF Research, 2007(6):492.
    Serrano M L, Sánchez-Gómez M, Bravo MM. Cervical scrapes levels of insulin-like growth factor-Ⅱ and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer [J]. Hormone and Metabolic Research, 2010, (13):977.
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出版历程
  • 发布日期:  2013-11-25

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