放疗、化疗综合治疗对局部中晚期鼻咽癌患者营养状态的影响

韦燕, 张芸, 易海振, 宁春玉

韦燕, 张芸, 易海振, 宁春玉. 放疗、化疗综合治疗对局部中晚期鼻咽癌患者营养状态的影响[J]. 实用临床医药杂志, 2013, (14): 94-96. DOI: 10.7619/jcmp.201314033
引用本文: 韦燕, 张芸, 易海振, 宁春玉. 放疗、化疗综合治疗对局部中晚期鼻咽癌患者营养状态的影响[J]. 实用临床医药杂志, 2013, (14): 94-96. DOI: 10.7619/jcmp.201314033
WEI Yan, ZHANG Yun, YI Haizhen, NING Chunyu. Influences of chemoradiotherapy on the nutritional status of patients with local middle-advanced nasopharyngeal carcinoma[J]. Journal of Clinical Medicine in Practice, 2013, (14): 94-96. DOI: 10.7619/jcmp.201314033
Citation: WEI Yan, ZHANG Yun, YI Haizhen, NING Chunyu. Influences of chemoradiotherapy on the nutritional status of patients with local middle-advanced nasopharyngeal carcinoma[J]. Journal of Clinical Medicine in Practice, 2013, (14): 94-96. DOI: 10.7619/jcmp.201314033

放疗、化疗综合治疗对局部中晚期鼻咽癌患者营养状态的影响

基金项目: 中国高校医学期刊临床专项资金
详细信息
  • 中图分类号: R734

Influences of chemoradiotherapy on the nutritional status of patients with local middle-advanced nasopharyngeal carcinoma

  • 摘要: 目的 评估放化疗综合治疗对局部中晚期鼻咽癌患者营养状态的影响.方法 观察50例接受放化疗综合治疗的局部中晚期鼻咽癌患者放疗前后体质量、体质量指数(BMI)、血常规、急性放射黏膜反应情况,应用营养风险筛查(NRS) 2002评估表评价患者的营养状态.结果 治疗后,患者体质量、BMI、白细胞计数(WBC)、红细胞计数(RBC)、血红蛋白(Hb)均较治疗前明显降低,而NRS评分较治疗前明显升高.接受普通放疗的患者出现Ⅱ度以上黏膜反应9例(90%),接受调强放疗的患者出现Ⅱ度以上黏膜反应22例(55%),二者比较差异显著.所有患者有轻度胃肠道反应,18例(36%)出现Ⅱ度胃肠道反应,无1例发生Ⅲ度以上胃肠道反应.结论 鼻咽癌患者放化疗时体质量下降及骨髓抑制对营养风险的发生影响较大,NRS 2002能较客观地反映被测者的营养风险,以便及早进行营养干预.
  • Chen Y, Sun Y, Liang S B. Progress report of a randomized trial comparing long-term survival and late toxicity of concurrentchemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage Ⅲ to IVB nasopharyngeal carcinoma from endemic regions of China [J]. Cancer, 2013, (12):2230.
    Jakob M, Manz M, Schrck A. Analysis of quality of life outcome for nasopharyngeal carcinoma patients after treatment [J]. Laryngo-Rhino-Otologie, 2013(4):244.
    Ferrari D, Chiesa F, Codecà C. Locoregionally advanced nasopharyngeal carcinoma:induction chemotherapy with cisplatin and 5-fluorouracil followed by radiotherapy and concurrent cisplatin:a phase Ⅱ study [J]. Oncology(Basel), 2008, (3-4):158.
    Bae W K, Hwang J E, Shim H J. Phase Ⅱ study of docetaxel, cisplatin, and 5-FU induction chemotherapy followed by chemoradiotherapy in locoregionally advanced nasopharyngeal cancer [J]. Cancer Chemotherapy and Pharmacology, 2010(3):589.
    Ravasco P, Monteiro Grillo I, Vidal P M. Dietary counseling improves patient outcomes:a prospective, randomized, controlled trial in colorectal cancerpatients undergoing radiotherapy [J]. Journal of Clinical Oncology, 2005(7):1431.
    Bauer J D, Capra S. Nutrition intervention improves outcomes in patients with cancer cachexia receiving chemotherapy-a pilot study [J]. Supportive Care in Cancer, 2005(4):270.
    陈绍萱, 滕忠爱, 张勇胜. 放疗对鼻咽癌患者营养状况影响的探讨 [J]. 广西医学, 2002(1):11.doi: 10.3969/j.issn.0253-4304.2002.05.004.
    Huang P Y, Wang C T, Cao K J. Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advancednasopharyngeal carcinoma treated with chemoradiotherapy:findings from a randomised trial [J]. European Journal of Cancer, 2013(8):1923.
    Qiu C, Yang N, Tian G. Weight loss during radiotherapy for nasopharyngeal carcinoma:a prospective study from northern China [J]. Nutrition and Cancer-an International Journal, 2011(6):873.
    Laouamri S, Hamdi Cherif M, Sekfali N. Dietary risk factors of nasopharyngeal carcinoma in the Setif area in Algeria [J]. Revue d Epidemiologie et de Sante Publique, 2001(2):145.
    胡小翠, 李云. 营养风险筛查2002和主观全面评定法在鼻咽癌患者中的应用比较 [J]. 医学理论与实践, 2011(2):134.doi: 10.3969/j.issn.1001-7585.2011.02.005.
计量
  • 文章访问数:  147
  • HTML全文浏览量:  23
  • PDF下载量:  6
  • 被引次数: 0
出版历程
  • 发布日期:  2013-10-14

目录

    /

    返回文章
    返回