阿托伐他汀对慢性心力衰竭患者血清脑钠肽水平及心功能的影响

王自毫; 蔡忠平; 黄永智

doi:10.7619/jcmp.201313031

阿托伐他汀对慢性心力衰竭患者血清脑钠肽水平及心功能的影响

广东省湛江农垦第二医院内三科,广东湛江,524000

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中图分类号: R541.6
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- 发布日期: 2013-10-15

Effect of atorvastatin on BNP and cardiac function in patients with chronic heart failure

摘要

摘要: 目的探讨阿托伐他汀对慢性心力衰竭(CHF)患者血清脑钠肽(BNP)水平及心功能的影响.方法将95例CHF患者随机分为治疗组和对照组.对照组给予常规ACEI、地高辛等基础治疗;治疗组进一步随机分为A、B、C共3个组,均在对照组基础上分别加用不同剂量的阿托伐他汀.治疗前及治疗后6、12周检测所有患者的左心室射血分数(LVEF)和血浆BNP浓度.结果与对照组比较,治疗组BNP下降水平和LVEF上升水平均更为显著(P＜0.05);治疗后6周,B、C组血浆BNP水平及LVEF均较A组显著降低(P＜0.05),但B、C组血浆BNP水平及LVEF经比较无显著差异(P＞0.05);治疗后12周,A、B、C组BNP水平及LVEF与同组治疗后第6周比较均无显著差异(P＞0.05).结论阿托伐他汀能明显降低CHF患者血浆BNP水平,改善LVEF,有利于CHF患者心功能的改善.
- 慢性心衰 /
- 脑钠肽 /
- 阿托伐他汀 /
- 左心室射血分数
- chronic heart failure /
- B-type natriuretic peptide /
- atorvastatin /
- left ventricular ejection fraction

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参考文献(13)

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文章访问数: 220
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阿托伐他汀对慢性心力衰竭患者血清脑钠肽水平及心功能的影响

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Effect of atorvastatin on BNP and cardiac function in patients with chronic heart failure

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