5-脂氧合酶在三阴性乳腺癌中的表达及其临床意义

孙弢, 姚宇锋, 龚建平, 唐金海

孙弢, 姚宇锋, 龚建平, 唐金海. 5-脂氧合酶在三阴性乳腺癌中的表达及其临床意义[J]. 实用临床医药杂志, 2013, (9): 119-120,129. DOI: 10.7619/jcmp.201309044
引用本文: 孙弢, 姚宇锋, 龚建平, 唐金海. 5-脂氧合酶在三阴性乳腺癌中的表达及其临床意义[J]. 实用临床医药杂志, 2013, (9): 119-120,129. DOI: 10.7619/jcmp.201309044
SUN Tao, YAO Yufeng, GONG Jianping, TANG Jinhai. Clinical significance of the 5-lipoxygenase expression in triple-negative breast cancer[J]. Journal of Clinical Medicine in Practice, 2013, (9): 119-120,129. DOI: 10.7619/jcmp.201309044
Citation: SUN Tao, YAO Yufeng, GONG Jianping, TANG Jinhai. Clinical significance of the 5-lipoxygenase expression in triple-negative breast cancer[J]. Journal of Clinical Medicine in Practice, 2013, (9): 119-120,129. DOI: 10.7619/jcmp.201309044

5-脂氧合酶在三阴性乳腺癌中的表达及其临床意义

详细信息
  • 中图分类号: R737.9

Clinical significance of the 5-lipoxygenase expression in triple-negative breast cancer

  • 摘要: 目的 探讨5-脂氧合酶(5-LOX)在三阴性乳腺癌(TNBC)中的表达及其临床意义.方法 免疫组化法检测178例TNBC组织中5-LOX的表达情况,分析其与临床病理特征的相关性,并通过随访,分析不同表达组的生存情况.结果 TNBC组织中5-LOX阳性表达率70.22% (125/178),其阳性表达与组织学分级、淋巴结转移呈正相关(P<0.05).随访显示5-LOX阴性表达组5年无复发生存率和总生存率明显高于阳性表达组(43%∶13%,96%∶91%).结论 5-LOX的阳性表达与TNBC的不良预后相关,可能成为TNBC治疗的新靶点.
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  • 发布日期:  2013-10-17

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