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NLRP3炎性体、IL-1和IL-18在突出腰椎间盘组织中的表达及意义

陈红峰, 吴小涛

陈红峰, 吴小涛. NLRP3炎性体、IL-1和IL-18在突出腰椎间盘组织中的表达及意义[J]. 实用临床医药杂志, 2013, (9): 40-43. DOI: 10.7619/jcmp.201309012
引用本文: 陈红峰, 吴小涛. NLRP3炎性体、IL-1和IL-18在突出腰椎间盘组织中的表达及意义[J]. 实用临床医药杂志, 2013, (9): 40-43. DOI: 10.7619/jcmp.201309012
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CHEN Hongfeng, WU Xiaotao. Expression and significance of NLRP3 inflammasome, IL-1 and IL-18 in herniated lumbar intervertebral disc issue[J]. Journal of Clinical Medicine in Practice, 2013, (9): 40-43. DOI: 10.7619/jcmp.201309012
Citation: CHEN Hongfeng, WU Xiaotao. Expression and significance of NLRP3 inflammasome, IL-1 and IL-18 in herniated lumbar intervertebral disc issue[J]. Journal of Clinical Medicine in Practice, 2013, (9): 40-43. DOI: 10.7619/jcmp.201309012
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NLRP3炎性体、IL-1和IL-18在突出腰椎间盘组织中的表达及意义

  • 1.

    江苏省南京市高淳区人民医院骨科,江苏南京,211300;

  • 2.

    东南大学附属中大医院脊柱外科,江苏南京,210009

基金项目: 中国高校医学期刊临床专项资金
详细信息

  • 中图分类号: R681.5

Expression and significance of NLRP3 inflammasome, IL-1 and IL-18 in herniated lumbar intervertebral disc issue

摘要

    摘要
  • 摘要: 目的 探讨核苷酸结合寡聚化结构域样受体含热蛋白结构域3(NLRP3)炎性体、白细胞介素(IL)-1、IL-18在突出腰椎间盘组织中的表达及意义.方法 将110例腰椎间盘组织标本分为突出组80例和非突出组30例.比较2组腰椎间盘组织中NLRP3、IL-1和IL-18表达及其在不同临床病理情况下的差异,并分析3者的相关性.结果 突出组椎间盘组织中NLRP3、IL-1和IL-18蛋白阳性表达率显著高于非突出组.3者阳性表达与性别、年龄、突出节段、疼痛部位均无显著相关性.NLRP3、IL-1蛋白阳性表达率随视觉模拟评分(VAS)的升高而增加,IL-18蛋白阳性表达率随VAS升高增加不甚明显,VAS≥7分和VAS≤3分间差异显著.3者在突出椎间盘组织中的表达呈正相关.结论 突出的腰椎间盘纤维环破裂以后,NL-RP3、IL-1、IL-18的表达率明显增加,其阳性表达率与临床疼痛程度相关,三者表达呈正相关.
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    • 参考文献(16)
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  • 发布日期:  2013-10-17

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