兔骨髓间充质干细胞与透明质酸钠复合修复软骨的实验研究

王琮仁, 张寿

王琮仁, 张寿. 兔骨髓间充质干细胞与透明质酸钠复合修复软骨的实验研究[J]. 实用临床医药杂志, 2013, (9): 1-4,8. DOI: 10.7619/jcmp.201309001
引用本文: 王琮仁, 张寿. 兔骨髓间充质干细胞与透明质酸钠复合修复软骨的实验研究[J]. 实用临床医药杂志, 2013, (9): 1-4,8. DOI: 10.7619/jcmp.201309001
WANG Congren, ZHANG Shou. Experimental research on compound repair of rabbit bone marrow mesenchymal stem cells and sodium hyaluronate to the cartilage[J]. Journal of Clinical Medicine in Practice, 2013, (9): 1-4,8. DOI: 10.7619/jcmp.201309001
Citation: WANG Congren, ZHANG Shou. Experimental research on compound repair of rabbit bone marrow mesenchymal stem cells and sodium hyaluronate to the cartilage[J]. Journal of Clinical Medicine in Practice, 2013, (9): 1-4,8. DOI: 10.7619/jcmp.201309001

兔骨髓间充质干细胞与透明质酸钠复合修复软骨的实验研究

基金项目: 中国高校医学期刊临床专项资金
详细信息
  • 中图分类号: R681.3

Experimental research on compound repair of rabbit bone marrow mesenchymal stem cells and sodium hyaluronate to the cartilage

  • 摘要: 目的 研究兔骨髓间充质干细胞(BM-MSCs)与透明质酸钠复合修复兔软骨缺损的作用.方法 在麻醉下制备18只家兔关节软骨缺损模型,将其随机分成3组.实验组(A组):BM-MSCs/透明质酸钠移植入软骨缺损处;对照组(B组):透明质酸钠移植入软骨缺损处;空白组(C组):不做处理.于移植后第6、12周分别对标本行组织学检测,并对实验数据行改良Pineda法评分,最后进行相关统计学分析.结果 A组为软骨样组织修复,组织学染色为阳性;B、C组软骨缺损处是以纤维组织为主的修复,组织学染色呈弱阳性.A组的修复效果显著优于B、C组,而B、C组之间的修复效果无明显差异.结论 移植的BM-MSCs/透明质酸钠复合物可有效促进兔软骨缺损修复.
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  • 发布日期:  2013-10-17

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