Comparison on the application of basal insulin and premixed insulin respectively combined with oral hypoglycemic agents in patients with type 2 diabetes mellitus
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摘要: 目的 探讨基础胰岛素与预混胰岛素联合口服降糖药在2型糖尿病患者的临床疗效.方法 将42例2型糖尿病患者随机分为联合基础胰岛素治疗组和联合预混胰岛素对照组,每组21例.2组患者均给予常规治疗,口服降糖药物、调节血脂、控制饮食和体质量.联合基础胰岛素治疗组在常规治疗基础上皮下注射基础胰岛素.联合预混胰岛素对照组在常规治疗基础上皮下注射预混胰岛素(30R).检测治疗前后空腹血糖(FBG)、餐后2h血糖(2hPG)水平,高压液相法测定HbAlc(糖化血红蛋白)水平.比较2组胰岛素注射剂量,观察血糖达标和低血糖事件发生情况.结果 与治疗前比较,2组治疗后FBG、2hPG、HbAlc水平均明显降低,联合基础胰岛素治疗组降低的更加明显.联合基础胰岛素治疗组胰岛素用量显著少于联合预混胰岛素对照组.2组患者治疗过程中出现低血糖事件均为轻度,进食后可缓解.结论基础胰岛素联合口服降糖药控制FPG、HbAlc效果较好,胰岛素用量较少.
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