血清雌二醇增幅对体外受精/卵浆内单精子注射-胚胎移植周期妊娠结局的预测价值

许虹; 陈烨; 周娜; 朱秀兰; 呙庆庆; 刘风华

doi:10.7619/jcmp.201307004

血清雌二醇增幅对体外受精/卵浆内单精子注射-胚胎移植周期妊娠结局的预测价值

广东省妇幼保健院生殖健康与不孕症科,广东广州,510010

基金项目: 中国高校医学期刊临床专项资金

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中图分类号: R714.15
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- 发布日期: 2013-06-12

Predictive value of serum estradiol amplification in pregnancy outcome of in-vitro fertilization/intracytoplasmic sperm injection-embryo transfer cycles

摘要

摘要: 目的探讨血清雌二醇(E2)增幅对体外受精/卵浆内单精子注射-胚胎移植(IVF/ICSI-ET)周期妊娠结局的预测价值.方法回顾性分析362例接受黄体中期长方案患者IVF/ICSI-ET周期的临床资料.以人绒毛膜促性腺激素(HCG)日次日血清E2水平/HCG日E2水平计算E2增幅,采用接受者操作特性曲线(ROC曲线)评价E2增幅和HCG日黄体酮(P)值对IVF/ICSI-ET周期临床妊娠的预测价值,并应用Pearson分析E2增幅与HCG日P值是否相关.结果妊娠组尿促卵泡素(FSH)启动量明显少于未妊娠组,且正常受精率、优质胚胎率和冷冻胚胎数均明显高于未妊娠组.ROC曲线结果显示E2增幅和HCG日P值用于预测临床妊娠有统计学意义,曲线下面积的95％可信区间分别为(0.507,0.625)和(0.508,0.626).HCG注射日P值与E2增幅呈负相关.结论 HCG日次日E2增幅和HCG日P值可有效衡量黄体中期长方案垂体降调节IVF/ICSI-ET患者HCG日的决定时机,能有效预测临床妊娠.
- 体外受精/卵浆内单精子注射-胚胎移植 /
- 人绒毛膜促性腺激素日 /
- 雌二醇增幅 /
- 临床妊娠

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参考文献(13)

倪郝, 陈雷宁, 全松. 长方案垂体降调节行IVF-ET时雌二醇水平变化的意义 [J]. 南方医科大学学报, 2011(2):365.

熊恰南. 黄体期血清雌孕激素变化对IVF-ET妊娠结局的影响 [D]. 武汉:华中科技大学, 2010.

Ozdegirmenci O, Dilbaz S, Cinar O. Can serum oestradiol be a predictor of quality of oocytes and embryos, maturation of oocytes and pregnancy rate in ICSI cycles [J]. Gynecological Endocrinology, 2011(4):279.

Kosmas I P, Kolibianakis E M, Devroey P. Association of estradiol levels on the day of hCG administration and pregnancy achievement in IVF:a systematic review [J]. Human Reproduction, 2004, (11):2446.

全松, 陈雷宁. 体外受精与辅助生殖Bourn Hall诊所临床实践与实验室操作指南 [M]. 北京:人民卫生出版社, 2009.126.

Kyrou D, Popovic-Todorovic B, Fatemi H M. Does the estradiol level on the day of human chorionic gonadotrophin administration have an impact on pregnancy rates in patients treated with rec-FSH/GnRH antagonist [J]. Human Reproduction, 2009, (11):2902.

Var T, Tonguc E, Dogan M. Relationship between the oestradiol/oocyte ratio and the outcome of assisted reproductive technology cycles with gonadotropin releasing hormone agonist [J]. Gynecological Endocrinology, 2011(8):558.

Joo B S, Park S H, An B M. Serum estradiol levels during controlled ovarian hyperstimulation influence the pregnancy outcome of in vitro fertilization in a concentration-dependent manner [J]. Fertility and Sterility, 2010(2):442.

Yen & Jaffe. 生殖内分泌学 [M]. 北京:人民卫生出版社, 2006.223.

郭洪胜, 李红, 全松. HCG注射日孕激素水平对卵巢储备能力正常者IVF妊娠结局的预测价值 [J]. 广东医学, 2009(9):1329.doi: 10.3969/j.issn.1001-9448.2009.09.050.

Younis J S, Matilsky M, Radin O. Increased progesterone/estradiol ratio in the late follicular phase could be related to low ovarian reserve in in vitro fertilization-embryo transfer cycles with a long gonadotropin-releasing hormone agonist [J]. Fertility and Sterility, 2001(2):294.

Bosch E, Valencia I, Escudero E. Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome [J]. Fertility and Sterility, 2003(6):1444.

Nikas G, Develioglu O H, Toner J P. Endometrial pinopodes indicate a shift in the window of receptivity in IVF cycles [J]. Human Reproduction, 1999(3):787.

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血清雌二醇增幅对体外受精/卵浆内单精子注射-胚胎移植周期妊娠结局的预测价值

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Predictive value of serum estradiol amplification in pregnancy outcome of in-vitro fertilization/intracytoplasmic sperm injection-embryo transfer cycles

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出版历程

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