Effects of atorvastatin on the endothelial progenitor cell function in peripheral blood of patients with coronary heart disease
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摘要: 目的 观察阿托伐他汀对冠心病患者外周血内皮祖细胞(EPCs)增殖、迁移、分化及集落形成能力的影响.方法 选择冠心病患者32例,从外周血获取单个核细胞,体外培养后进行细胞分析和计数.结果 EPCs的数量、增殖率、贴壁细胞及迁移细胞数量均随阿托伐他汀用药时间的延长而增加.结论 阿托伐他汀能提高内皮祖细胞(EPCs)的增殖及分化能力.
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Briasoulis A, Tousoulis D, Androulakis E S. Endothelial dysfunction and atherosclerosis:focus on novel therapeutic approaches [J]. Recent Pat Cardiovasc Drug Discov, 2012(1):21. Hirase T, Node K. Endothelial dysfunction as a cellular mechanism for vascular failure [J]. American Journal of Physiology-Heart and Circulatory Physiology, 2012(3):499. Deshmukh H A, Colhoun H M, Johnson T. Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy:importance of Lp(a) [J]. Journal of Lipid Research, 2012(5):1000. Davignon J. Beneficial cardiovascular pleiotropic effects of statins [J]. Circulation, 2004, (23 Suppl 1):Ⅲ39. Llevadot J, Murasawa S, Kureishi Y. HMG-CoA reductase inhibitor mobilizes bone marrow--derived endothelial progenitor cells [J]. Journal of Clinical Investigation, 2001(3):399. Loomans C J, van Haperen R, DnijsJ M. Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia [J]. Molecular Medicine, 2009, (5/6):152. Dimmeler S, Aicher A, Vasa M. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway [J]. Journal of Clinical Investigation, 2001(3):391. Matsumura M, Fukuda N, Kobayashi N. Effects of atorvastatin on angiogenesis in hindlimb ischemia and endothelial progenitor cell formation in rats [J]. Journal of Atherosclerosis and Thrombosis, 2009(4):319. Ma F X, Chen F, Ren Q. Lovastatin restores the function of endothelial progenitor cells damaged by oxLDL [J]. Acta Pharmacologica Sinica, 2009(5):545. 董志兵, 张怀勤. 他汀类药物与内皮祖细胞 [J]. 心血管病学进展, 2009(2):341.doi: 10.3969/j.issn.1004-3934.2009.02.046.
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