胃癌组织中Ezrin表达及其意义

张汀荣

张汀荣. 胃癌组织中Ezrin表达及其意义[J]. 实用临床医药杂志, 2013, (5): 33-35. DOI: 10.7619/jcmp.201305009
引用本文: 张汀荣. 胃癌组织中Ezrin表达及其意义[J]. 实用临床医药杂志, 2013, (5): 33-35. DOI: 10.7619/jcmp.201305009
ZHANG Tingrong. Expression of Ezrin in gastric cancer and its significance[J]. Journal of Clinical Medicine in Practice, 2013, (5): 33-35. DOI: 10.7619/jcmp.201305009
Citation: ZHANG Tingrong. Expression of Ezrin in gastric cancer and its significance[J]. Journal of Clinical Medicine in Practice, 2013, (5): 33-35. DOI: 10.7619/jcmp.201305009

胃癌组织中Ezrin表达及其意义

详细信息
  • 中图分类号: R735.2

Expression of Ezrin in gastric cancer and its significance

  • 摘要: 目的 探讨埃兹蛋白在胃癌组织中的表达及其意义.方法 分别选取胃癌组织标本40例、不典型增生胃黏膜组织标本20例及正常胃黏膜组织标本10例,检测分析其Ezrin mRNA及蛋白的表达及意义,检测方法采用原位杂交及免疫组化法.结果 EzrinmRNA和蛋白阳性表达率,胃癌组织<不典型增生胃黏膜<正常胃黏膜,且三者差异有统计学意义(P<0.01);在不同浸润深度、肿瘤大小及有无淋巴结转移组内Ezrin mRNA和蛋白阳性表达率有明显的差异(P<0.05),但在年龄、性别和脉管侵犯组内没有明显的差异(P>0.05);Ezrin mRNA正比于蛋白表达率(rs=0.99,P<0.01).结论 胃癌产生、发展及转移在很大程度上会导致Ezrin表达下降.
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出版历程
  • 发布日期:  2013-06-12

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