脱氢表雄酮对卵巢储备功能低下患者卵巢功能的改善及不孕症的治疗作用分析

陈碧晖; 高瑞花; 刘奇志; 谭玉彬

doi:10.7619/jcmp.201303032

脱氢表雄酮对卵巢储备功能低下患者卵巢功能的改善及不孕症的治疗作用分析

广东省广州市番禺区何贤纪念医院生殖医学科,广东广州,511400

基金项目: 中国高校医学期刊临床专项资金

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中图分类号: R271.14
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- 文章访问数: 129
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- 发布日期: 2013-05-22

Analysis of therapeutic effects of dehydroepiandrosterone on the ovarian function and infertility of patients with declinein ovarian reserve

摘要

摘要: 目的观察脱氢表雄酮(DHEA)对卵巢储备功能低下患者卵巢功能及不孕症的治疗效果.方法选择本院收泊的诱发排卵失败且卵巢指标证明为卵巢储备功能下降的患者28例,口服DHEA 3个月后再次尝试诱发排卵治疗.比较患者口服DHEA前后卵巢储备指标的变化,观察不孕症的临床结局.结果患者月经周期第3天卵泡刺激素(FSH)、FSH/黄体生成素(LH)、雌二醇(E2)明显下降,窦卵泡计数(AFC)明显上升,显示患者的卵巢功能得到显著改善.患者经3个周期治疗,排卵率达78.3％,累计临床妊娠率达46.4％,流产率为15.4％,其余11例患者均足月产下1活胎,无畸形婴儿出生.结论 DHEA可有效改善卵巢功能及助孕结局.
- 脱氢表雄酮 /
- 卵巢储备功能 /
- 不孕症 /
- 排卵 /
- 临床妊娠

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参考文献(11)

刘阳, 蔡霞. 卵巢储备功能与辅助生殖技术治疗结局 [J]. 国际生殖健康/计划生育杂志, 2009(5):305.doi: 10.3969/j.issn.1674-1889.2009.05.007.

Kyrou D, Kolibianakis E M, VenetisCA. How toimprove the probability of pregnancy in poor responders undergoing in vitro fertilization:a systematic review and meta analysis [J]. Fertility and Sterility, 2009(3):749.

Abramovich D, Irusta G, Bas D. Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome [J]. Endocrinology, 2012(7):3446.

张阳阳. 脱氢表雄酮在妇产科领域的应用研究 [J]. 国际生殖健康/计划生育杂志, 2012(4):291.doi: 10.3969/j.issn.1674-1889.2012.04.013.

陈士岭. 卵巢储备功能的评价 [J]. 国际生殖健康/计划生育杂志, 2009(5):281.doi: 10.3969/j.issn.1674-1889.2009.05.001.

Burger H G. Androgen production in women [J]. Fertility and Sterility, 2002, (Suppl 4):S3.

Casson P R, Santoro N, Elkind-Hirsch K. Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-Ⅰ and decreases high-density lipoprotein:a six-month trial [J]. Fertility and Sterility, 1998(1):107.

HaningR V Jr, Hackett R J, Flood C A. Plasrna dehydrocpiandrosterone sulfate serves as a prehormone for 48 % of follicular fluid testosterone during treatment with menotropins [J]. Journal of Clinical Endocrinology and Metabolism, 1993(5):1301.

Anderson E, Lee G Y, O'Brien K. Polycystic ovarian condition in the dehydroepiandrosterone-treated rat model:hyperandrogenism and the resumption of meiosis are major initial events associated with cystogenesis of antral follicles [J]. Anatomical Record, 1997(1):44.

Gleicher N, Weghofer A, Barad D. The perpetually "young"oocyte:ovarian environments for follicular maturation age but not unrecruited, resting primordial follicles/oocytes [J]. Fertility and Sterility, 2010(4):S139.

Morales A J, Nolan J J, Nelson J C. Effect of replacement dose of dehydroepiandrosterone in men and women of advancing age [J]. Journal of Clinical Endocrinology and Metabolism, 1994(6):1360.

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文章访问数: 129
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脱氢表雄酮对卵巢储备功能低下患者卵巢功能的改善及不孕症的治疗作用分析

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Analysis of therapeutic effects of dehydroepiandrosterone on the ovarian function and infertility of patients with declinein ovarian reserve

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