胃黏膜病变组织中RASAL1基因的表达及其与幽门螺杆菌感染的关系

夏挺松; 钱建忠; 徐洪明; 刘鹏飞; 项斌; 刘兵团

doi:10.7619/jcmp.201301009

胃黏膜病变组织中RASAL1基因的表达及其与幽门螺杆菌感染的关系

1.
东南大学医学院附属江阴医院消化科,江苏江阴,214400;
2.
东南大学医学院附属江阴医院病理科,江苏江阴,214400

基金项目: 中国高校医学期刊临床专项资金

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中图分类号: R573
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- 发布日期: 2013-05-01

Expression of RASAL1 in gastric mucosa lesions and its relationship with helicobacter pylori infection

摘要

摘要: 目的探讨RASAL1基因在幽门螺杆菌(Hp)感染胃黏膜组织中的变化及其在胃癌发生发展中的意义.方法内镜及活检病理证实的慢性胃炎58例(慢性胃炎组)、肠化生及异型增生58例(肠化生及异型增生组)和胃癌58例(胃癌组),分别用13C-呼气试验及Giemsa染色检测Hp,链霉菌亲生物素蛋白-过氧化物酶连接(SP)免疫组化检测RASAL1,比较各组及组内Hp阳性亚组和Hp阴性亚组中RASAL1的表达.结果慢性胃炎组、肠化生及异型增生组和胃癌组中RASAL1的阳性率分别为89.66％、56.90％和13.79％,呈递减趋势.各组Hp阳性亚组与Hp阴性亚组中RASAL1的阳性率分别为,慢性胃炎组:73.33％和96.43％,肠化生及异型增生组:40.63％和76.92％,胃癌组:14.29％与13.51％,两两比较均有显著差异.结论 Hp感染可降低胃黏膜RASAL1表达,削弱其对胃黏膜损伤的保护作用,促进了胃癌的发生发展.
- RASAL1 /
- 幽门螺杆菌 /
- 胃黏膜

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参考文献(10)

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文章访问数: 309
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胃黏膜病变组织中RASAL1基因的表达及其与幽门螺杆菌感染的关系

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出版历程

Expression of RASAL1 in gastric mucosa lesions and its relationship with helicobacter pylori infection

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出版历程

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