Comparison of antitumor effect between nedaplatin and cisplatin on bladder carcinoma cell line BIU- 87 in vivo and in vitro
-
摘要: 目的 比较奈达铂与顾铂对膀胱癌细胞系BIU - 87的体内外杀伤作用及毒副作用.方法 用MTT法检测比较奈达铂与顺铂对BIU - 87细胞系的抑制率;用裸鼠接种实验检测比较奈达铂与顺铂对裸鼠BIU- 87移植瘤的抑制作用及毒性作用.结果 奈达铂在体外对BIU - 87细胞系的抑制率与顺铂相似,但对裸鼠移植瘤抑制力更强.奈达铂毒性反应较轻.结论 在膀胱癌化疗中,奈达铂可能比顺铂更具优势.
-
-
Desoize B, Madoulet C. Particular aspects of platinum compounds used at present in cancer treatment [J]. Critical Reviews in Oncology/Hematology, 2002(3):317. 涂正生, 彭小娟, 刑军. SGC7901细胞对化疗药物的敏感性研究 [J]. 江西医学院学报, 2007(1):84.doi: 10.3969/j.issn.1000-2294.2007.01.027. 杨敬儒, 金和坤, 江啸音. 奈达铂与调强适形同步放化疗治疗期食管癌疗效分析 [J]. 实用临床医药杂志, 2011, (15):75.doi: 10.3969/j.issn.1672-2353.2011.15.026. Osaka Y, Takawa R, Hoshino S. Combination chemotherapy with docetaxel and nedaplatin for recurrent esophageal cancer in an outpatient setting [J]. Diseases of the Esophagus, 2006(6):473.doi: 10.1111/j.1442-2050.2006.00614.x. 7Fujita Y, Hiramatsu M, Kawai M. Evaluation of combined docetaxel and nedaplatin chemotherapy for recurrent esophageal cancer compared with conventional chemotherapy using cisplatin and 5-fluorouracil:a retrospective study [J]. Diseases of the Esophagus, 2008(6):496.doi: 10.1111/j.1442-2050.2007.00806.x. Hirose T, Hosaka T, Nakashima M. Two cases with recurrent non-small cell lung cancer successfully treated with cisplatin and S-1 [J]. Gan to Kagaku Ryoho(Japanese Journal of Cancer and Chemotherapy), 2008(2):327. 林玉成, 王建化, 王玉斌. 同步低剂景奈达铂联合超分割放疗治疗局部晚期非小细胞肺癌的临床Ⅰ/Ⅱ期研究 [J]. 中国癌症杂志, 2010, (12):934. 张玉婷, 赵纯全. 宫颈癌新辅助化疗药物的临床研究 [J]. 中国药房, 2010, (46):4385. Shinohara N, Harabayashi T, Suzuki S. Salvage chemotherapy with paclitaxel, ifosfamide, and nedaplatin in patients with urothelial cancer who had received prior cisplatin-based therapy [J]. Cancer Chemotherapy and Pharmacology, 2006(3):402.doi: 10.1007/s00280-005-0175-4. Uehara T, Watanabe H, Itoh F. Nephrotoxicity of a novel antineoplastic platinum complex, nedaplatin;a comparative study with cisplatin in rats [J]. Archives of Toxicology, 2005(8):451.doi: 10.1007/s00204-005-0648-6.
计量
- 文章访问数: 134
- HTML全文浏览量: 30
- PDF下载量: 10
下载:
苏公网安备 32100302010246号
