垂体肿瘤转化基因及碱性成纤维细胞生长因子在乳腺癌组织中的表达及意义

卜迟文; 杨全德; 刘景宏; 陈茜

doi:10.3969/j.issn.1672-2353.2012.07.005

垂体肿瘤转化基因及碱性成纤维细胞生长因子在乳腺癌组织中的表达及意义

江苏省灌云县人民医院,江苏连云港,222200

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中图分类号: R737.9
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- 发布日期: 2012-10-23

Expressions and significance of pituitary tumor - transforming gene and basic fibroblast growth factor in breast carcinoma

摘要

摘要: 目的研究垂体肿瘤转化基因(PTTG)及碱性成纤维细胞生长因子(bFGF)在乳腺癌中的表达及意义.方法收集乳腺癌患者手术标本72例,癌旁正常乳腺组织20例.通过免疫组化方法检测PTTG和bFGF的表达,随访观察发生转移情况及5年生存率.结果 PTIG及bFGF在正常乳腺组织中呈阴性表达,在乳腺癌组织中呈阳性表达,高表达者其发生远处转移的几率及死亡率均明显高于低表达者,且PTTG及bFGF间存在相关关系.结论 PTTG及bFGF参与乳腺癌的形成及发展,其表达高低与乳腺癌的恶性程度及预后相关.在标本中对其行半定量分析可对乳腺癌患者的治疗及预后提供重要的参考.
- 垂体肿瘤转化基因 /
- 碱性成纤维细胞生长因子 /
- 乳腺癌

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参考文献(13)

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文章访问数: 307
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垂体肿瘤转化基因及碱性成纤维细胞生长因子在乳腺癌组织中的表达及意义

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Expressions and significance of pituitary tumor - transforming gene and basic fibroblast growth factor in breast carcinoma

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