Effect of glucocorticoid administration method on bone mineral density in rats
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摘要: 目的 观察不同的糖皮质激素给药方法对大鼠骨密度的影响.方法 将80只雌性SD大鼠随机分为5组(A、B、C、D、E组),其中A组大鼠作为阴性对照,给予溶剂5 mL/(kg·d)灌胃；B组大鼠给予强的松5mg/(kg·d)灌胃；C组大鼠给予强的松10 mg/(kg·2 d);D组大鼠给予强的松10 mg/(kg·2 d);E组大鼠静脉给予强的松80 mg/(kg·d)×3d,每4周1次,A、B、C、E组观察12周,D组观察24周,分别检测实验前后大鼠椎骨骨密度、血清PTH、血清25羟维生素D3水平.结果 与A组相比,B、C、D组血清PTH水平明显升高,血清25羟维生素D3水平及椎骨骨密度明显下降；E组各项指标的变化无统计学意义.与B组比较,C组大鼠血清PTH水平变化无统计学意义,而血清25羟维生素D3水平及椎骨骨密度的变化有统计学意义,变化程度低于B组；而D组大鼠指标变化程度均大于B组.结论 与每日持续使用糖皮质激素相比较,虽然总量相同,但隔日用药对骨密度的影响较小,而长时间用药对骨密度影响大,而短时间大剂量使用激素,对骨密度的影响则不明显.
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