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糖耐量受损和2型糖尿病患者脂联素水平的相关性研究

孙斌, 黄珊

孙斌, 黄珊. 糖耐量受损和2型糖尿病患者脂联素水平的相关性研究[J]. 实用临床医药杂志, 2012, (1): 33-35. DOI: 10.3969/j.issn.1672-2353.2012.01.009
引用本文: 孙斌, 黄珊. 糖耐量受损和2型糖尿病患者脂联素水平的相关性研究[J]. 实用临床医药杂志, 2012, (1): 33-35. DOI: 10.3969/j.issn.1672-2353.2012.01.009
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SUN Bin, HUANG Shan. Evaluation of adiponectin level in association with impaired glucose tolerance and type 2 diabetes[J]. Journal of Clinical Medicine in Practice, 2012, (1): 33-35. DOI: 10.3969/j.issn.1672-2353.2012.01.009
Citation: SUN Bin, HUANG Shan. Evaluation of adiponectin level in association with impaired glucose tolerance and type 2 diabetes[J]. Journal of Clinical Medicine in Practice, 2012, (1): 33-35. DOI: 10.3969/j.issn.1672-2353.2012.01.009
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糖耐量受损和2型糖尿病患者脂联素水平的相关性研究

  • 上海市长宁区中心医院,上海,200336

详细信息

  • 中图分类号: R446.11+2 R587.1

Evaluation of adiponectin level in association with impaired glucose tolerance and type 2 diabetes

摘要

    摘要
  • 摘要: 目的 探讨在糖耐量受损及2型糖尿病患者中血脂血糖、胰岛素抵抗和血清脂联素之间的关系.方法 166例分为正常对照组(29例)、糖耐量受损组(41例)和糖尿病组(96例),分别检测血脂、血糖、血胰岛素水平和血清脂联素,采用HOMA- IR法计算胰岛素抵抗指数.分别对正常组是否进展为糖耐量受损,以及糖耐量受损是否进展为糖尿病进行二分类Logistic回归分析.结果 正常对照组、糖耐量受损组和糖尿病组血清脂联素水平分别为(15.8±3.6)、(10.7±2.4)和(6.3±2.4) mg/L,3组间差异有显著统计学意义(P＜0.05).糖耐量受损组的体质指数、总胆固醇、胰岛素水平和胰岛素抵抗显著高于正常组(P均＜0.05).Logistic回归分析表明体质指数、高密度脂蛋白胆固醇、空腹胰岛素、胰岛素抵抗指数为正常对照进展为糖耐量受损的危险因素.当糖耐量受损组进展为糖尿病组时,空腹胰岛素是唯一有统计学差异的危险因素.脂联素在两个阶段中都为保护因素.结论 在糖耐量受损时胰岛素抵抗水平升高,并已伴随脂联素水平下降.血清脂联素测定,可作为2型糖尿病的辅助诊断、及早干预的指标.
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    • 参考文献(9)
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出版历程
  • 发布日期:  2012-04-26

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