-
摘要: 近年来肿瘤的治疗疗取得了相当大的进展,但在不同种族人群或个体间仍存在显著的治疗敏感性和不良反应的差异.目前常用的抗肿瘤化疗药物对患者治疗的有效性不仅低于70％,而且,由于缺乏化疗药物个体化治疗的遗传学分析,使20％～40％的患者甚至有可能接受了错误的药物治疗,同样病理类型、病期甚至分子表型相同的患者在接受相同方案治疗后可能产生"天壤之别"的结果[1].临床医生在遇到这种情况时,唯一能告诉患者家属的原因就是"个体化差异",深入来讲就是基因表达的不同,导致肿瘤细胞对化疗药物的敏感性不同,从而产生不同的结果.转化医学的出现有助于实现肿瘤的个体化治疗,有可能达到"同病异治,异病同治"的境界.
-
-
Janelsins M C, Kohli S, Mohile S G. An update on cancer-and chemotherapy-related cognitive dysfunction current status [J]. Seminars in Oncology, 2011(3):431. 杨春喜, 殷宁, 戴魁戎. 转化医学 [J]. 中华医学杂志, 2010(7):499.doi: 10.3760/cma.j.issn.0376-2491.2010.07.019. Geraghty J. Adenomatous polyposis coli and translational medicine [J]. Lancet, 1996, (9025):422. DiGiusto D L, Kfishnan A, Li L. RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34 +Cells in Patients Undergoing T ransplantation for AIDS Related Lymphoma [J]. Science Translational Medicine, 2010, (36):36. Wu C L, Jordan K W, Ratai E M. Metabolomic Imaging for Human Prostate Cancer Detection [J]. Science Translational Medicine, 2010, (16):16. Wei W, Li B, Hanes M A. S-Nitrosylation from GSNOR Deftciency.Impairs DNA Repair and Promotes Hepatocarcinogenesis [J]. Scienee Translational Medicine, 2010, (19):13. Gustafson A M, Soldi R, Anderlind C. Airway PI3K pathway activation is an early and reversible event in lung cancer development [J]. Science Translational Medicine, 2010, (26):25. Miehelakis E D, Sutendra G, Dromparis P. Metabolic modulation of glioblastoma with dichloroacetate [J]. Science Translational Medicine, 2010, (31):31. Uramoto H, Mitsudomi T. Which biomarker predicts benefit from EGFR-TKI treatment for patients with lung cancer [J]. British Journal of Cancer, 2007(6):857. 曾益新. 肿瘤学转化医学思路 [J]. 协和医学杂志, 2011(2):117.doi: 10.3969/j.issn.1674-9081.2011.02.003.
计量
- 文章访问数: 154
- HTML全文浏览量: 29
- PDF下载量: 13
下载:
苏公网安备 32100302010246号
