非小细胞肺癌分子靶向药物转化医学研究的过去、现状与未来

王欣欣, 陈正堂

王欣欣, 陈正堂. 非小细胞肺癌分子靶向药物转化医学研究的过去、现状与未来[J]. 实用临床医药杂志, 2012, (1): 9-13,16. DOI: 10.3969/j.issn.1672-2353.2012.01.003
引用本文: 王欣欣, 陈正堂. 非小细胞肺癌分子靶向药物转化医学研究的过去、现状与未来[J]. 实用临床医药杂志, 2012, (1): 9-13,16. DOI: 10.3969/j.issn.1672-2353.2012.01.003

非小细胞肺癌分子靶向药物转化医学研究的过去、现状与未来

基金项目: 军队临床高新技术重大项目,国家自然科学基金
详细信息
  • 中图分类号: R730.5

  • 摘要: 非小细胞肺癌(NSCLC)的病死率高,治疗颇为棘手.令人欣慰的是,近年来,随着基础医学研究的深入,在NSCLC发病中起重要作用的相关分子靶点陆续被发现,并且,这些基础研究的重大进展已转化为临床实际应用的成果.其中,最具标志的是一批针对这些靶点的靶向药物的研发,如单克隆抗体西妥昔单抗和小分子酪氨酸激酶抑制剂(TKI)吉非替尼(Iressa,易瑞沙)等.目前,这些药物已成功应用于临床并取得显著疗效,开创了NSCLC分子靶向治疗的新时代.在这复杂而漫长的基础医学研究直至药物研发的过程中,转化医学真正地从一个概念发展为推动新药研发的"引擎",促进了基础医学研究向临床应用的迅速转化,为广大患者带来了福音.作者就NSCLC靶向药物TKI的研发历程做一综述,谈谈转化医学在肺癌治疗中的重要作用和临床意义.
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出版历程
  • 发布日期:  2012-04-26

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