Tramadol with Flurbiprofen Axetil reduces recovery restlessness after general anesthesia
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摘要: 目的 观察曲马朵联合氟比洛芬酯用于预防全麻手术苏醒期躁动的效果及安全性.方法 择期腹腔镜胆囊切除手术60例,随机分为3组,每组20例.A组:于麻醉诱导开始前给予氟比洛芬酯注射液1 mg/kg;B组:于手术停止前20 min给予曲马朵注射液2 mg/kg;C组:于麻醉诱导开始前给予氟比洛芬酯注射液1mg/kg,手术停止前20 min给予曲马朵注射液2 mg/kg.观察:每组患者拔管即刻(0min),拔管后5min,10 min,15 min的躁动评分；从停药到患者清醒的时间；是否发生呼吸抑制、恶心呕吐、皮肤瘙痒等不良反应.结果 各时间点躁动分级:A组明显高于B组和C组,B组明显高于C组(P＜0.01).B、C组各有1例恶心、呕吐发生,3组无呼吸抑制、凝血功能异常、瘙痒等不良反应,3组之间差异无显著性意义.结论 术中应用曲马朵联合氟比洛芬酯对预防全麻苏醒期躁动具有良好的效果,并能降低不良反应发生率.
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