Clinical observation of zoledronic acid on metastatic bone of breast cancer
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摘要: 目的 观察国产唑来膦酸(因力达)治疗乳腺痛骨转移的临床疗效和不良反应.方法 国产唑来膦酸4mg加入0.9%生理盐水100 mL静脉滴注15 min,1次/4周,持续治疗6个月后评估疗效及不良反应.结果 唑来膦酸治疗患者骨痛、骨转移病灶、生活活动能力的有效率分别为83.3%、66.7%、75.0%；血液指标异常例数较治疗前有所减少,异常率有下降趋势,但治疗前后比较无统计学差异；不良反应为发热1例(4.2%),肌肉荚节酸痛2例(8.3%),全身及末梢水肿1例(4.2%),经对症治疗后消失.结论 国产唑来膦酸(因力达)治疗乳腺癌骨转移疗效肯定,不良反应发生率低,是临床治疗乳腺癌骨转移的优选方法.
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