Effect of nebulized budesonide on acute exacerbation of chronic obstructive pulmonary disease
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摘要: 目的 评价局部吸入布地奈德治疗慢性阻塞性肺疾病急性加重期的疗效及安全性.方法 选择60例COPD急性加重期住院患者随机均分为3 组:① 布地奈德组给予布地奈德雾化液雾化吸入2 mg/次,每8小时1次;②泼尼松组给予口服泼尼松片30 mg/次,每日1次;③ 空白对照组不使用任何糖皮质激素.观察3组患者治疗后呼吸困难评分、肺功能和动脉血气变化.结果 与空白对照组比较,布地奈德组、泼尼松组在治疗后呼吸困难评分、动脉血气及肺功能的改善有显著性差异(P＜0.05).布地奈德组与泼尼松组在提高FEV1、PaO2,改善呼吸困难评分方面无显著性差异(P＞0.05).但在PaCO2值下降方面,在治疗7 d后布地奈德组下降(4.4±1.5) mmHg,泼尼松组下降(5.3±2.2) mmHg,两组比较有显著性差异(P＜0.05).布地奈德组的不良反应少于泼尼松组.结论 布地奈德组的疗效明显优于空白对照组,但与泼尼松组的无显著性差异.局部吸入布地奈德溶液是COPD 急性加重期有效选择.
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