MG132、顺铂联合用药对Caov-3细胞中NF-κB、VEGF表达的影响

顾光华; 张磊; 李彩霞

doi:10.3969/j.issn.1672-2353.2010.17.007

MG132、顺铂联合用药对Caov-3细胞中NF-κB、VEGF表达的影响

1.
江苏省溧阳市人民医院,妇产科,江苏,溧阳,213300;
2.
江苏省扬州市妇幼保健院,妇产科,江苏,扬州,225001;
3.
江苏省昆山中医院妇产科,江苏,昆山,215300

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中图分类号: R737.31
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- 发布日期: 2010-12-15

Expressions of NF-κB and VEGF in Caov-3 cells after the administration of MG132 combined with DDP

摘要

摘要: 目的研究蛋白酶体抑制剂MG132与DDP联合用药前后卵巢癌细胞株Caov-3细胞内NF-κB、VEGF表达情况.方法免疫组化SP法测定用药前后Caov-3细胞中NF-κB、VEGF的表达情况.结果免疫组化结果显示MG132、DDP联合用药作用24 h后Caov-3细胞中NF-κB、VEGF表达均下调,与对照组、DDP组比较差异有显著性(P<0.01),联合用药组各组间两两比较差异有显著性(P<0.01).结论 MG132能通过抑制NF-κB活性诱导卵巢癌细胞Caov-3凋亡,抑制肿瘤血管生长.
- 卵巢癌 /
- 蛋白酶体抑制剂(MG132) /
- 顺铂(DDP) /
- Caov-3 /
- NF-κB /
- VEGF

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参考文献(15)

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文章访问数: 240
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MG132、顺铂联合用药对Caov-3细胞中NF-κB、VEGF表达的影响

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出版历程

Expressions of NF-κB and VEGF in Caov-3 cells after the administration of MG132 combined with DDP

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出版历程

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