Effect of losartan on renal fibrosis in Type 2 diabetic nephropathy
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摘要: 目的 通过检测糖尿病肾病患者尿转化生长因子β1(TGFβ1水平,探讨患者肾脏纤维化状况及氯沙坦对肾脏纤维化的影响.方法 检测33例2型糖尿病肾病患者氯沙坦(50 mg/d×8周治疗前后24 h尿蛋白、尿肌酐,尿TGFβ1和肌酐.尿TGFβ1检测方法为ELISA法.20例健康志愿者的尿液标本作为对照组.结果 糖尿病肾病患者尿TGFβ1明显高于正常对照组,经氯沙坦治疗后尿TGFβ1浓度明显下降(P<0.001.尿TGFβ1浓度变化与尿蛋白变化具有相关性(P<0.01).结论 氯沙坦通过降低槠尿病肾病患者尿TGFβ1水平发挥抗肾脏纤维化作用,这是氯沙坦延缓糖尿病肾病进展的机制之一,这一表现先于蛋白尿的减少.
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关键词:
- 糖尿病肾病 /
- 氯沙坦 /
- 尿转化生长因子β1(TGFβ1)
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US Renal Data System Excerpts from the United States Renal Data System 2001Annual Data Report:Atlas of End-Stage Renal Disease in the United States [J]. American Journal of Kidney Diseases, 2001.S1. Brenner B M, Cooper M E, de Zeeuw D. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy [J]. New England Journal of Medicine, 2001, (12):861.doi: 10.1056/NEJMoa011161. Lewis E J, Hunsicker L G, Clarke W R. Reno[rotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes [J]. New England Journal of Medicine, 2001, (12):851.doi: 10.1056/NEJMoa011303. Goumenos D S, Tsakas S, EI Nahas AM. Transforming growth factor-β1 in the kidney and urine of patients with glomerual disease and proteinuria [J]. Nephrology Dialysis Transplantation, 2002, (12):2145.doi: 10.1093/ndt/17.12.2145. Border W A, Noble N A. Interactions of transforming growth factor-β and angiotensin Ⅱ in renal fibrosis [J]. Hypertension, 1998(1):181.
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