急性颅脑损伤后血清TNF-α和IL-18的含量变化及临床意义

韦俐; 周鹏; 袁志诚

doi:10.3969/j.issn.1672-2353.2009.03.014

急性颅脑损伤后血清TNF-α和IL-18的含量变化及临床意义

1.
江苏省镇江市第一人民医院,检验科,江苏,镇江,212002;
2.
江苏省镇江市第一人民医院,神经外科,江苏,镇江,212002

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中图分类号: R651.1
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- 发布日期: 2009-04-14

Changes and clinical significance of serum TNF-α and IL-18 contents in patients with acute brain trauma

摘要

摘要: 目的探讨急性颅脑损伤后血清肿瘤坏死因子α(TNF-α)和白细胞介素18(IL-18)的含量变化及临床意义.方法采用酶联免疫吸附(ELISA)法测定60例急性颅脑损伤患者伤后第1、3、7、10天血清TNF-α和IL-18的含量,观察TNF-α和IL-18血清含量的变化规律,分析颅脑损伤程度与TNF-α和IL-18含量之间的关系.结果 TNF-α在伤后早期即明显升高,于伤后第3天达到高峰,至第10天下降明显,但仍高于对照组(P＜0.05);IL-18含量在伤后呈逐渐升高趋势,并在第10天达到高峰.重型颅脑损伤组在伤后各个时间点的血清TNF-α和IL-18含量较轻、中型组明显升高(P＜0.05).结论急性颅脑损伤后血清TNF-α和IL-18含量明显升高,与颅脑损伤程度呈正相关;TNF-α和IL-18参与了急性颅脑损伤后的炎性反应过程,在继发性脑损害中起重要作用.
- 急性颅脑损伤 /
- 肿瘤坏死因子α /
- 白细胞介素18

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参考文献(13)

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急性颅脑损伤后血清TNF-α和IL-18的含量变化及临床意义

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出版历程

Changes and clinical significance of serum TNF-α and IL-18 contents in patients with acute brain trauma

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出版历程

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