DKK-3和WIF-1基因启动子甲基化状态与肝细胞癌的关系研究

丁振, 钱叶本, 熊奇如, 余宏铸, 李方跃, 张超, 许业传

丁振, 钱叶本, 熊奇如, 余宏铸, 李方跃, 张超, 许业传. DKK-3和WIF-1基因启动子甲基化状态与肝细胞癌的关系研究[J]. 实用临床医药杂志, 2009, (3): 12-15,20. DOI: 10.3969/j.issn.1672-2353.2009.03.004
引用本文: 丁振, 钱叶本, 熊奇如, 余宏铸, 李方跃, 张超, 许业传. DKK-3和WIF-1基因启动子甲基化状态与肝细胞癌的关系研究[J]. 实用临床医药杂志, 2009, (3): 12-15,20. DOI: 10.3969/j.issn.1672-2353.2009.03.004
DING Zhen, QIAN Ye-ben, XIONG Qi-ru, YU Hong-zhu, LI Fang-yue, ZHANG Chao, XU Ye-chuan. Promoter methylation and mRNA expression of DKK-3 gene in hepatocellular carcinoma[J]. Journal of Clinical Medicine in Practice, 2009, (3): 12-15,20. DOI: 10.3969/j.issn.1672-2353.2009.03.004
Citation: DING Zhen, QIAN Ye-ben, XIONG Qi-ru, YU Hong-zhu, LI Fang-yue, ZHANG Chao, XU Ye-chuan. Promoter methylation and mRNA expression of DKK-3 gene in hepatocellular carcinoma[J]. Journal of Clinical Medicine in Practice, 2009, (3): 12-15,20. DOI: 10.3969/j.issn.1672-2353.2009.03.004

DKK-3和WIF-1基因启动子甲基化状态与肝细胞癌的关系研究

基金项目: 安徽省教育厅自然科学基金
详细信息
  • 中图分类号: R735.7

Promoter methylation and mRNA expression of DKK-3 gene in hepatocellular carcinoma

  • 摘要: 目的 探讨DKK-3和WIF-1基因启动子甲基化状态与肝细胞癌发生的相关性.方法 应用甲基化特异性聚合酶链反应检测33例肝细胞癌及相应的癌旁组织和20例正常对照肝组织中DKK-3和WIF-1基因启动子甲基化状态,分析上述组织中两种基因甲基化状态与临床资料的关系.结果 DKK-3和WIF-1基因在癌组织中甲基化率明显高于癌旁组织和正常组织(P<0.05, P<0.05), 而癌旁组织和正常组织中DKK-3和WIF-1基因甲基化率相比无明显差异;癌组织中DKK-3基因甲基化与临床资料中年龄及肝硬化有关;癌组织中WIF-1基因甲基化与临床资料中乙肝表面抗原、肝硬化有关.结论 DKK-3和WIF-1基因启动子甲基化与HCC的发生相关;DKK-3和WIF-1基因致肝细胞癌的发生机制可能与肝硬化致肝细胞癌的发生机制不尽相同,两者是否有相互作用尚不清楚.
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出版历程
  • 发布日期:  2009-04-14

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