洛伐他汀减轻冈田酸诱导的大鼠皮质神经元Tau蛋白过度磷酸化

马涛, 陈耀民, 赵永波

马涛, 陈耀民, 赵永波. 洛伐他汀减轻冈田酸诱导的大鼠皮质神经元Tau蛋白过度磷酸化[J]. 实用临床医药杂志, 2008, (5): 34-37,48. DOI: 10.3969/j.issn.1672-2353.2008.05.009
引用本文: 马涛, 陈耀民, 赵永波. 洛伐他汀减轻冈田酸诱导的大鼠皮质神经元Tau蛋白过度磷酸化[J]. 实用临床医药杂志, 2008, (5): 34-37,48. DOI: 10.3969/j.issn.1672-2353.2008.05.009
MA Tao, CHEN Yao-min, ZHAO Yong-bo. Lovastatin Attenuates Okadaic acid-induced Tau Protein Superphosphorylation in Rat Cortical Neurons[J]. Journal of Clinical Medicine in Practice, 2008, (5): 34-37,48. DOI: 10.3969/j.issn.1672-2353.2008.05.009
Citation: MA Tao, CHEN Yao-min, ZHAO Yong-bo. Lovastatin Attenuates Okadaic acid-induced Tau Protein Superphosphorylation in Rat Cortical Neurons[J]. Journal of Clinical Medicine in Practice, 2008, (5): 34-37,48. DOI: 10.3969/j.issn.1672-2353.2008.05.009

洛伐他汀减轻冈田酸诱导的大鼠皮质神经元Tau蛋白过度磷酸化

基金项目: 美国阿尔茨海默氏症协会基金
详细信息
  • 中图分类号: R741.02

Lovastatin Attenuates Okadaic acid-induced Tau Protein Superphosphorylation in Rat Cortical Neurons

  • 摘要: 目的 探讨洛汀 (LOV)对冈田酸(OA)诱导的大鼠皮质神经元Tau蛋白过度磷酸化的影响.方法 选用孕期17d的SD大鼠,取皮质神经元接种培养.待优化OA处理时间和剂量等条件后,实验分为阴性对照组、OA组、LOV组、LOV预处理+OA组.通过免疫印迹法检测皮层神经元Tau蛋白磷酸化水平、总Tau蛋白水平.结果应用OA 30 nmmol/L处理大鼠皮质神经元1 h,成功诱导Tau蛋白过度磷酸化,而不明显影响细胞活力.LOV 500 nM预处理4 d能在Thr181 (AT270),Thr231 (AT180),Ser202/Thr205 (AT8)和Ser396等磷酸化位点显著减轻冈田酸诱导的大鼠皮质神经元Tau蛋白过度磷酸化,而不影响总Tau蛋白水平.结论 洛伐他汀减轻冈田酸诱导的大鼠皮质神经元Tau蛋白过度磷酸化,提示洛伐他汀对Tau相关神经病理有潜在的神经保护作用.
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  • 发布日期:  2008-09-23

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