NRAMP1基因DNA多态性与海南黎族人结核病易感性的研究

林容; 薄建萍; 蔡望伟; 李羲; 林峰; 赵平锋

doi:10.3969/j.issn.1672-2353.2008.01.012

NRAMP1基因DNA多态性与海南黎族人结核病易感性的研究

1.
海南医学院附属医院呼吸内科,海南,海口,570102;
2.
山西医科大学第二医院呼吸内科,山西,太原,030001;
3.
海南省结核病防治所,海南,海口,570203

基金项目: 海南省自然科学基金

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中图分类号: R521
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出版历程
- 发布日期: 2008-07-13

Study on relationship between DNA polymorphisms of natural resistance associated macrophage protein 1 gene and susceptibility to tuberculosis in Hainan Li ethnic group

摘要

摘要: 目的探讨自然抵抗相关巨噬细胞蛋白1(NRAMPl)基因D543N和3'UTR位点多态性与海南黎族人结核病易感性的关系.方法采用病例对照研究设计,共有130例肺结核病例和233例对照纳人本研究,用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析的方法检测入选人群NRAMPl基因中D543N和3'UTR位点的多态性,并对结核病相关危险因素进行问卷调查,进行单因素和基因频率的分析.结果对所有研究对象进行D543N和3'UTR两个多态性位点的基因分型,3'UTR-TGTG+/TGTG-和3'UTR-TGTG-/TGTG-基因型病例组频率显著高于对照组,OR值分别为5.531(2.649-11.549)和0.181(0.087-0.378);D543N位点各基因型频率在病例和对照组中的频率无显著性差异;同时对4个相关危险因素进行了单因素分析,结果性别、酗酒两个因素在病例组和对照组中有显著性差异,OR值(95%CI)分别为3.937(2.459-6.304)和2.435(1.507-3.937),在多因素分析中,调整了性别、吸烟、酗酒3个因素后,3'UTR-TGTG+/TGTG-和3'UTR-TGTG/TGTG-基因型仍与肺结核显著相关,OR值(95%CI)分别为5.140(2.394-11.034)和4.929(2.769-8.775).结论 NRAMPl基因3'UTR位点多态性可能是海南黎族人结核病的易感因素,D543N位点多态性与海南黎族人结核病的发生无关.
- 肺结核 /
- NRAMPl基因,多态性 /
- 疾病易感性

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参考文献(14)

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文章访问数: 163
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NRAMP1基因DNA多态性与海南黎族人结核病易感性的研究

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出版历程

Study on relationship between DNA polymorphisms of natural resistance associated macrophage protein 1 gene and susceptibility to tuberculosis in Hainan Li ethnic group

计量

出版历程

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