白三烯受体拮抗剂和激素对哮喘小鼠精氨酸酶-Ⅰ转录水平影响的研究

滕鸿, 胡敏, 刘春涛, 刘跃建, 梁宗安

滕鸿, 胡敏, 刘春涛, 刘跃建, 梁宗安. 白三烯受体拮抗剂和激素对哮喘小鼠精氨酸酶-Ⅰ转录水平影响的研究[J]. 实用临床医药杂志, 2007, (9): 35-39. DOI: 10.3969/j.issn.1672-2353.2007.09.010
引用本文: 滕鸿, 胡敏, 刘春涛, 刘跃建, 梁宗安. 白三烯受体拮抗剂和激素对哮喘小鼠精氨酸酶-Ⅰ转录水平影响的研究[J]. 实用临床医药杂志, 2007, (9): 35-39. DOI: 10.3969/j.issn.1672-2353.2007.09.010
TENG Hong, HU Min, LIU Chun-tao, LIU Yue-Jian, LIANG Zong-an. A Study on the Effects of Cysteinyl Leukotriene Receptor Antagonist and Dexamethasone on the Transcription Level of Arginase-Ⅰ in Asthmatic Mouse Models[J]. Journal of Clinical Medicine in Practice, 2007, (9): 35-39. DOI: 10.3969/j.issn.1672-2353.2007.09.010
Citation: TENG Hong, HU Min, LIU Chun-tao, LIU Yue-Jian, LIANG Zong-an. A Study on the Effects of Cysteinyl Leukotriene Receptor Antagonist and Dexamethasone on the Transcription Level of Arginase-Ⅰ in Asthmatic Mouse Models[J]. Journal of Clinical Medicine in Practice, 2007, (9): 35-39. DOI: 10.3969/j.issn.1672-2353.2007.09.010

白三烯受体拮抗剂和激素对哮喘小鼠精氨酸酶-Ⅰ转录水平影响的研究

详细信息
  • 中图分类号: R562.2

A Study on the Effects of Cysteinyl Leukotriene Receptor Antagonist and Dexamethasone on the Transcription Level of Arginase-Ⅰ in Asthmatic Mouse Models

  • 摘要: 目的 观察哮喘小鼠模型的病理特点及精氨酸酶-Ⅰ在哮喘小鼠中的转录水平及白三烯受体拮抗剂和激素干预对精氨酸酶-Ⅰ转录水平的影响.方法 建立小鼠哮喘模型;实验分为对照组、哮喘组、孟鲁司特(MK)干预组、地塞米松(DXM)干预组;图像分析肺内支气管平滑肌厚度;阿尔新兰染色,观察粘液分泌情况;半定量PCR检测精氨酸酶-Ⅰ mRNA水平.结果 哮喘组出现管壁增厚、平滑肌增生、粘液分泌增加、炎症细胞浸润等特征,精氨酸酶-Ⅰ mRNA水平明显增高;MK组、DXM组与哮喘组比较,炎症反应轻微,平滑肌增生、粘液分泌不明显;DXM组精氨酸酶-mRNA水平降低,与哮喘组比较差异有显著性.结论 少量、多次变应原吸入可导致气道炎症和重构,精氨酸酶-Ⅰ在哮喘小鼠中的表达水平升高, DXM干预可降低精氨酸酶-ⅠmRNA水平,一定程度上延缓气道重构的发生.
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出版历程
  • 发布日期:  2008-01-23

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