高同型半胱氨酸血症与急性脑血管病及颈动脉狭窄的关系

李军; 沈志梅; 朱艳; 杨扬; 赵海宁; 王晓铃

doi:10.3969/j.issn.1672-2353.2006.11.012

高同型半胱氨酸血症与急性脑血管病及颈动脉狭窄的关系

1.
江苏省苏北人民医院,神经内科,江苏,扬州,225001;
2.
江苏省苏北人民医院,老年科,江苏,扬州,225001;
3.
江苏省苏北人民医院,中心实验室,江苏,扬州,225001

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中图分类号: R5
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- 发布日期: 2007-01-14

THE RELATIONSHIP BETWEEN HYPERHOMOCYSTEINEMIA AND ACUTE CEREBROVASCULAR DISEASE AND CAROTID STENOSIS

摘要

摘要: 目的研究高同型半胱氨酸血症(Hhcy)与急性脑血管病及颈动脉狭窄的关系.方法应用荧光定量分析法测定68例急性脑梗死(ACI组)、52例急性脑出血(AICH组)患者血浆同型半胱氨酸(Hcy)浓度,放免方法测定各组的叶酸、维生素B12水平,并与正常对照组比较.对脑梗死患者采用彩色多普勒超声进行颈动脉检测.结果 ACI组、AICH组的血浆Hcy水平均显著高于正常对照组(均P＜0.01), 而叶酸、维生素B12水平均显著低于正常对照组(均P＜0.05).单因素相关分析显示ACI组、AICH组血浆Hcy水平与叶酸水平均呈负相关(r=-0.37、-0.34, P＜0.01), 与维生素B12水平也均呈负相关(r=-0.33、-0.29, P＜0.01).ACI组中,颈动脉重度狭窄者血浆Hcy浓度显著高于中度狭窄者及无狭窄或轻度狭窄者(均P＜0.01), 中度狭窄者血浆Hcy浓度显著高于无狭窄或轻度狭窄者(P＜0.01).结论 Hhcy是急性脑血管病的一个新的重要危险因素.Hcy水平受叶酸、维生素B12的影响, Hcy水平与脑梗死患者颈动脉狭窄的严重程度有关.
- 急性脑血管病 /
- 同型半胱氨酸 /
- 叶酸 /
- 维生素B12 /
- 颈动脉狭窄

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参考文献(15)

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文章访问数: 156
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高同型半胱氨酸血症与急性脑血管病及颈动脉狭窄的关系

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出版历程

THE RELATIONSHIP BETWEEN HYPERHOMOCYSTEINEMIA AND ACUTE CEREBROVASCULAR DISEASE AND CAROTID STENOSIS

计量

出版历程

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