DETECTING CHROMOSOME 13 DELETION IN MULTIPLE MYELOMA WITH FLUORESCENCE IN SITU HYBRIDIZATION
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摘要: 目的 探讨多发性骨髓瘤(MM)中13号染色体缺失的情况.方法 运用SpectrumOrangeTM标记的位于13q14的序列特异性DNA探针D13S319和荧光原位杂交(FISH)技术对37例MM患者的细胞进行染色体13q14的检测.结果 37例MM中12例(32.4%)有del(13q14).结论 FISH是一种在分析MM患者del(13q14)异常方面较为快速、准确和敏感的方法, del(13q14)在MM中的意义有待进一步探讨.
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