伊马替尼治疗Ph阳性慢性髓细胞白血病急变期及急性淋巴细胞白血病39例

金正明, 吴德沛, 孙爱宁, 仇惠英, 唐晓文

金正明, 吴德沛, 孙爱宁, 仇惠英, 唐晓文. 伊马替尼治疗Ph阳性慢性髓细胞白血病急变期及急性淋巴细胞白血病39例[J]. 实用临床医药杂志, 2005, (8): 53-54,56. DOI: 10.3969/j.issn.1672-2353.2005.08.031
引用本文: 金正明, 吴德沛, 孙爱宁, 仇惠英, 唐晓文. 伊马替尼治疗Ph阳性慢性髓细胞白血病急变期及急性淋巴细胞白血病39例[J]. 实用临床医药杂志, 2005, (8): 53-54,56. DOI: 10.3969/j.issn.1672-2353.2005.08.031

伊马替尼治疗Ph阳性慢性髓细胞白血病急变期及急性淋巴细胞白血病39例

详细信息
  • 中图分类号: R557

  • 摘要: 甲磺酸伊马替尼[STI-571(格列卫)]是瑞士诺华公司生产的一种强有力的选择性酪氨酸激酶抑制剂,可特异性地抑制Ph+白血病克隆增殖.国外报道其在慢性髓细胞白血病慢性期(CML-CP)患者的治疗中显示了良好的疗效,且毒副作用较小[1, 2].也有用于慢性髓细胞白血病加速期(CML-AP)、急变期(CML-BP)及Ph染色体阳性的急性淋巴细胞白血病(Ph+-ALL)患者的少数报道[3~6].作者2002年6月~2004年10月共使用该药治疗CML-BP及难治/复发Ph+-ALL患者39例,现总结报告如下.
  • Druker B J, Talpaz M, Resta D J, et a1. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia [J]. New England Journal of Medicine, 2001, (14):1031.doi: 10.1056/NEJM200104053441401.
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    Sawyers C L, Hochhaus A, Feldman E. Imatinib mesylate induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis:results of a phase Ⅱ study [J]. Blood, 2002.3530.doi: 10.1182/blood.V99.10.3530.
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    Walters R S, Kantarjian H M, Keating M J. Therapy of lymphoid and undifferentiated chronic myelogenous leukemia in blast crisis with continuous vincristine and adriamycin infusions plus high-dose decadron [J]. CANCER, 1987.1708.doi: 10.1002/1097-0142(19871015)60:8<1708::AID-CNCR2820600803>3.0.CO;2-1.
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出版历程
  • 发布日期:  2005-10-19

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