大鼠短暂脑缺血术后行为学的评价

苗宏生, 惠国桢

苗宏生, 惠国桢. 大鼠短暂脑缺血术后行为学的评价[J]. 实用临床医药杂志, 2004, (3): 32-35. DOI: 10.3969/j.issn.1672-2353.2004.03.012
引用本文: 苗宏生, 惠国桢. 大鼠短暂脑缺血术后行为学的评价[J]. 实用临床医药杂志, 2004, (3): 32-35. DOI: 10.3969/j.issn.1672-2353.2004.03.012
BEHAVIORAL ASSESSMENT IN RAT WITH MIDDLE CEREBRAL ARTERY OCCLUSION[J]. Journal of Clinical Medicine in Practice, 2004, (3): 32-35. DOI: 10.3969/j.issn.1672-2353.2004.03.012
Citation: BEHAVIORAL ASSESSMENT IN RAT WITH MIDDLE CEREBRAL ARTERY OCCLUSION[J]. Journal of Clinical Medicine in Practice, 2004, (3): 32-35. DOI: 10.3969/j.issn.1672-2353.2004.03.012

大鼠短暂脑缺血术后行为学的评价

详细信息
  • 中图分类号: R743.31

BEHAVIORAL ASSESSMENT IN RAT WITH MIDDLE CEREBRAL ARTERY OCCLUSION

  • 摘要: 目的观察大脑中动脉阻塞(MCAO) 2 h造成的短暂脑缺血大鼠(MCAO大鼠)行为学表现.方法采用插线法阻塞成年SD大鼠大脑中动脉制作短暂脑缺血模型,分别对模型大鼠进行神经行为学、四肢协调性及学习记忆能力检查;术后第14天处死大鼠取脑组织进行四氮唑红(TTC)染色鉴定模型的成功与否.对照组不进行动脉阻塞.结果术后1 h至第14天, MCAO大鼠与对照组比较,在神经行为学、协调性及学习记忆能力等方面均有明显的缺失和障碍(P<0.01).结论采用插线法制作的大鼠短暂脑缺血模型操作简单;术后动物行为学实验是1种半定量分析,具有敏感、客观的特点,能够广泛应用于各种实验研究.
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出版历程
  • 发布日期:  2004-08-25

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