体外循环急性肺损伤与基质金属蛋白酶-9相关性研究

王常田; 景华; 李忠东; 胡小南; 董国华; 钱建军; 罗立国; 顾卫东

doi:10.3969/j.issn.1672-2353.2003.06.004

体外循环急性肺损伤与基质金属蛋白酶-9相关性研究

南京军区南京总医院,心胸外科,江苏,南京,210002

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中图分类号: R654.1
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- 发布日期: 2004-07-30

RELATIONSHIP BETWEEN MATRIX METALLOPROTEINASE-9 AND ACUTE LUNG INJURY DURING CARDIOPULMONARY BYPASS

摘要

摘要: 目的探讨基质金属蛋白酶-9(MMP-9)在围体外循环术(CPB)中的变化及其与急性肺损伤的相关性.方法临床选择20例接受CPB的患者,分别测定CPB开始、开始后5 min、结束时、结束后1 h和结束后6 h血浆MMP-9和TNF-α浓度,同时测定CPB结束后各时间点的A-aDO2、呼吸指数,记录主动脉阻断时间、转流时间及拔管时间,分析血浆MMP-9和TNF-α在围CPB期间的变化以及与影响因素和肺功能之间的相关性.结果①血浆MMP-9和TNF-α的浓度在CPB结束时达到最高峰值,之后呈下降趋势; ②血浆MMP-9的升高与TNF-α升高呈正相关, CPB结束时血浆MMP-9浓度与主动脉阻断时间最有相关性; ③CPB结束后A-aDO2的变化与术后血浆MMP-9浓度的变化有相关性,而RI变化与MMP-9之间未见有相关性.结论 CPB可以引起血浆MMP-9和TNF-α浓度的明显增高,其中主动脉阻断时间对CPB结束时血浆MMP-9的影响最为明显.CPB过程中MMP-9与TNF-α之间存在着相关性, MMP-9浓度与CPB结束后A-aDO2的变化有相关性.
- 体外循环 /
- 基质金属蛋白酶-9 /
- 肿瘤坏死因子-α /
- 肺损伤

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参考文献(11)

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文章访问数: 160
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体外循环急性肺损伤与基质金属蛋白酶-9相关性研究

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出版历程

RELATIONSHIP BETWEEN MATRIX METALLOPROTEINASE-9 AND ACUTE LUNG INJURY DURING CARDIOPULMONARY BYPASS

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